Macrophages are commonly thought to contribute to the pathophysiology of preterm labor by
amplifying inflammation—but a protective role has not previously been considered to our …

Preterm birth is the leading cause of neonatal morbidity and mortality worldwide. One of
every 4 preterm neonates is born to a mother with intra-amniotic inflammation driven by …

Labor is a complex physiological process requiring a well-orchestrated dialogue between
the mother and fetus. However, the cellular contributions and communications that facilitate …

Preterm birth remains the leading cause of neonatal morbidity and mortality worldwide. A
substantial number of spontaneous preterm births occur in the context of sterile intra …

The timely onset of female parturition is a critical determinant for pregnancy success. The
highly heterogenous maternal decidua has been increasingly recognized as a vital factor in …

Intrauterine infection/inflammation (IUI) is a major contributor to preterm labor (PTL).
However, IUI does not invariably cause PTL. We hypothesized that quantitative and …

Introduction Despite intensive research, preterm birth (PTB) rates have not decreased
significantly in recent years due to a lack of understanding of the underlying causes and …

The underlying mechanisms governing parturition remain largely elusive due to limited
knowledge of parturition preparation and initiation. Accumulated evidences indicate that …

Adverse pregnancy outcomes including maternal mortality, stillbirth, preterm birth,
intrauterine growth restriction cause millions of deaths each year. More effective …

Vaginal dysbiosis, such as bacterial vaginosis (BV) and aerobic vaginitis (AV), is an
important cause of premature birth in pregnant women. However, there is very little research …