Ageing is a process that inevitably affects most living organisms and involves the
accumulation of macromolecular damage, genomic instability and loss of heterochromatin …

The aging population and the incidence of aging-related diseases such as osteoporosis are
on the rise. Aging at the tissue and organ levels usually involves tissue stem cells. Human …

SIRT6 belongs to the mammalian homologs of Sir2 histone NAD+-dependent deacylase
family. In rodents, SIRT6 deficiency leads to aging-associated degeneration of mesodermal …

Cellular senescence is a driver of various aging-associated disorders, including
osteoarthritis. Here, we identified a critical role for Yes-associated protein (YAP), a major …

CBX4, a component of polycomb repressive complex 1 (PRC1), plays important roles in the
maintenance of cell identity and organ development through gene silencing. However …

Aims: Cellular senescence and its secretory phenotype (senescence-associated secretory
phenotype [SASP]) develop after long-term expansion of mesenchymal stromal cells …

Abstract Age-related (type-II) osteoporosis is a common and debilitating condition driven in
part by the loss of bone marrow (BM) mesenchymal stromal cells (MSC) and their osteoblast …

Organismal aging involves the progressive decline in organ function and increased
susceptibility to age-associated diseases. Regardless of its origin, cellular aging is …

Aging is an important risk factor in the occurrence of many chronic diseases. Senescence
and exhaustion of adult stem cells are considered as a hallmark of aging in organisms. In …

Dyskeratosis congenita (DC) is a rare genetic disorder characterized by deficiencies in
telomere maintenance leading to very short telomeres and the premature onset of certain …