Aortic valve stenosis: from basic mechanisms to novel therapeutic targets
Aortic valve stenosis is the most prevalent heart valve disease worldwide. Although
interventional treatment options have rapidly improved in recent years, symptomatic aortic …
interventional treatment options have rapidly improved in recent years, symptomatic aortic …
Extracellular vesicles, inflammation, and cardiovascular disease
A Akhmerov, T Parimon - Cells, 2022 - mdpi.com
Cardiovascular disease is a leading cause of death worldwide. The underlying mechanisms
of most cardiovascular disorders involve innate and adaptive immune responses, and …
of most cardiovascular disorders involve innate and adaptive immune responses, and …
Spatiotemporal multi-omics mapping generates a molecular atlas of the aortic valve and reveals networks driving disease
Background: No pharmacological therapy exists for calcific aortic valve disease (CAVD),
which confers a dismal prognosis without invasive valve replacement. The search for …
which confers a dismal prognosis without invasive valve replacement. The search for …
Extracellular vesicles are integral and functional components of the extracellular matrix
K Rilla, AM Mustonen, UT Arasu, K Härkönen… - Matrix Biology, 2019 - Elsevier
Extracellular vesicles (EV) are small plasma membrane-derived particles released into the
extracellular space by virtually all cell types. Recently, EV have received increased interest …
extracellular space by virtually all cell types. Recently, EV have received increased interest …
Multiomics of tissue extracellular vesicles identifies unique modulators of atherosclerosis and calcific aortic valve stenosis
BACKGROUND: Fewer than 50% of patients who develop aortic valve calcification have
concomitant atherosclerosis, implying differential pathogenesis. Although circulating …
concomitant atherosclerosis, implying differential pathogenesis. Although circulating …
Cardiovascular calcification: artificial intelligence and big data accelerate mechanistic discovery
Cardiovascular calcification is a health disorder with increasing prevalence and high
morbidity and mortality. The only available therapeutic options for calcific vascular and …
morbidity and mortality. The only available therapeutic options for calcific vascular and …
Annexin A1–dependent tethering promotes extracellular vesicle aggregation revealed with single–extracellular vesicle analysis
Extracellular vesicles (EVs) including plasma membrane–derived microvesicles and
endosomal-derived exosomes aggregate by unknown mechanisms, forming …
endosomal-derived exosomes aggregate by unknown mechanisms, forming …
Extracellular vesicles as mediators of cardiovascular calcification
A Bakhshian Nik, JD Hutcheson… - Frontiers in cardiovascular …, 2017 - frontiersin.org
Involvement of cell-derived extracellular particles, coined as matrix vesicles (MVs), in
biological bone formation was introduced by Bonucci and Anderson in mid-1960s. In 1983 …
biological bone formation was introduced by Bonucci and Anderson in mid-1960s. In 1983 …
[HTML][HTML] Glycosylation in extracellular vesicles: Isolation, characterization, composition, analysis and clinical applications
V Vrablova, N Kosutova, A Blsakova, A Bertokova… - Biotechnology …, 2023 - Elsevier
This review provides a comprehensive overview of our understanding of the role that
glycans play in the formation, loading and release of extracellular vesicles (EVs). The …
glycans play in the formation, loading and release of extracellular vesicles (EVs). The …
Mitochondrial dysfunction: cause or consequence of vascular calcification?
K Phadwal, C Vrahnas, IG Ganley… - Frontiers in cell and …, 2021 - frontiersin.org
Mitochondria are crucial bioenergetics powerhouses and biosynthetic hubs within cells,
which can generate and sequester toxic reactive oxygen species (ROS) in response to …
which can generate and sequester toxic reactive oxygen species (ROS) in response to …