The central inflammatory regulator IκBζ: induction, regulation and physiological functions

Y Feng, Z Chen, Y Xu, Y Han, X Jia, Z Wang… - Frontiers in …, 2023 - frontiersin.org
IκBζ (encoded by NFKBIZ) is the most recently identified IkappaB family protein. As an
atypical member of the IkappaB protein family, NFKBIZ has been the focus of recent studies …

Progress in PRRSV infection and adaptive immune response mechanisms

H Cai, H Zhang, H Cheng, M Liu, S Wen, J Ren - Viruses, 2023 - mdpi.com
Since its discovery, Porcine reproductive and respiratory syndrome (PRRS) has had a huge
impact on the farming industry. The virus that causes PRRS is Porcine Reproductive and …

Zinc Oxide–Selenium Nanoparticles for Inhibiting the Proliferation of Porcine Reproductive and Respiratory Syndrome Virus

Y Xu, Q Li, Y Chen, Y Zhang, W Yang… - ACS Applied Nano …, 2024 - ACS Publications
Porcine Reproductive and Respiratory Syndrome (PRRS) is an acute, highly contagious
swine infectious disease caused by the PRRS virus (PRRSV). Due to the frequent mutation …

Comparison of pathogenicity and host responses of emerging porcine reproductive and respiratory syndrome virus variants in piglets

W Zhang, X Wang, H Zhang, Y Pan, W Ma, Y Xu… - Journal of …, 2024 - journals.asm.org
Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly variable virus with
genetic diversity. This study comparatively examines the pathogenicity and immunological …

[HTML][HTML] Alveolar Macrophages in Viral Respiratory Infections: Sentinels and Saboteurs of Lung Defense

P Pöpperl, M Stoff, A Beineke - International Journal of Molecular …, 2025 - mdpi.com
Respiratory viral infections continue to cause pandemic and epidemic outbreaks in humans
and animals. Under steady-state conditions, alveolar macrophages (AlvMϕ) fulfill a …

Single-cell transcriptomics of bronchoalveolar lavage during PRRSV infection with different virulence

B Lim, SC Kim, HJ Kim, JH Kim, YJ Seo, C Lim… - Nature …, 2025 - nature.com
Porcine reproductive and respiratory syndrome virus (PRRSV) causes significant economic
losses in the global swine industry due to its high genetic diversity and different virulence …

Rapid conversion of porcine pluripotent stem cells into macrophages with chemically defined conditions

X Wu, Y Ni, W Li, B Yang, X Yang, Z Zhu… - Journal of Biological …, 2024 - ASBMB
A renewable source of porcine macrophages derived from pluripotent stem cells (PSCs)
would be a valuable alternative to primary porcine alveolar macrophages (PAMs) in the …

Porcine reproductive and respiratory syndrome virus adapts antiviral innate immunity via manipulating MALT1

H Gu, S Zheng, G Han, H Yang, Z Deng, Z Liu, F He - Mbio, 2022 - Am Soc Microbiol
To fulfill virus replication and persistent infection in hosts, viruses have to find ways to
compromise innate immunity, including timely impedance on antiviral RNases and …

PRRSV-1 induced lung lesion is associated with an imbalance between costimulatory and coinhibitory immune checkpoints

I Ruedas-Torres, JM Sánchez-Carvajal… - Frontiers in …, 2023 - frontiersin.org
Porcine reproductive and respiratory syndrome virus (PRRSV) induces a dysregulation on
the innate and adaptive immune responses. T-cell activation requires a proper interaction …

Calcium-mediated mitochondrial fission and mitophagy drive glycolysis to facilitate arterivirus proliferation

Z Sun, Z Ma, W Cao, C Jiang, L Guo, K Liu… - PLoS …, 2025 - journals.plos.org
Mitochondria, recognized as the “powerhouse” of cells, play a vital role in generating cellular
energy through dynamic processes such as fission and fusion. Viruses have evolved …