During the last four decades, proliferative vitreoretinopathy (PVR) has defied the efforts of
many researchers to prevent its occurrence or development. Thus, PVR is still the major …

Familial exudative vitreoretinopathy (FEVR) is a rare inherited disorder of retinal
angiogenesis. Cases can be autosomal dominant, autosomal recessive, or X-linked. FEVR …

Canonical WNT signaling is required for proper vascularization of the CNS during
embryonic development. Here, we used mice with targeted mutations in genes encoding …

β-Catenin signaling controls the development and maintenance of the blood–brain barrier
(BBB) and the blood–retina barrier (BRB), but the division of labor and degree of …

Frizzled proteins are the principal receptors for the Wnt family of ligands. They mediate
canonical Wnt signaling together with Lrp5 and Lrp6 coreceptors. In conjunction with Celsr …

Purpose To describe the diversity of clinical findings associated with familial exudative
vitreoretinopathy (FEVR) using wide-field angiography and to update the current …

Objective To describe the prevalence and severity of familial exudative vitreoretinopathy
(FEVR) in asymptomatic relatives of known symptomatic FEVR patients. Design …

Importance Retinal detachment with avascularity of the peripheral retina, typically
associated with familial exudative vitreoretinopathy (FEVR), can result from mutations …

Myopia is the most common cause of visual impairment worldwide. Genetic and
environmental factors contribute to the development of myopia. Studies on the molecular …

Familial exudative vitreoretinopathy (FEVR) is an inherited blinding disorder characterized
by the abnormal development of the retinal vasculature. The majority of mutations identified …