Overview of the manufacturing methods of solid dispersion technology for improving the solubility of poorly water-soluble drugs and application to anticancer drugs

P Tran, YC Pyo, DH Kim, SE Lee, JK Kim, JS Park - Pharmaceutics, 2019 - mdpi.com
Approximately 40% of new chemical entities (NCEs), including anticancer drugs, have been
reported as poorly water-soluble compounds. Anticancer drugs are classified into biologic …

Pharmaceutical dispersion techniques for dissolution and bioavailability enhancement of poorly water-soluble drugs

X Zhang, H Xing, Y Zhao, Z Ma - Pharmaceutics, 2018 - mdpi.com
Over the past decades, a large number of drugs as well as drug candidates with poor
dissolution characteristics have been witnessed, which invokes great interest in enabling …

Cilostazol-loaded solid lipid nanoparticles: Bioavailability and safety evaluation in an animal model

M Bibi, F ud Din, Y Anwar, NA Alkenani, AT Zari… - Journal of Drug Delivery …, 2022 - Elsevier
Cilostazol (CLZ) is an antiplatelet agent with limited solubility (∼ 6 μg/ml at 25° C), poor
absorption and low oral bioavailability. In this study, solid lipid nanoparticles (SLNs) were …

[PDF][PDF] RETRACTED ARTICLE: Potential of solid dispersions to enhance solubility, bioavailability, and therapeutic efficacy of poorly water-soluble drugs: newer …

S Alshehri, SS Imam, A Hussain, MA Altamimi… - Drug …, 2020 - Taylor & Francis
Abstract We, the Editors and Publisher of Drug Delivery have retracted the following article:
Sultan Alshehri, Syed Sarim Imam, Afzal Hussain, Mohammad A. Altamimi, Nabil K …

Development, Characterization, and Evaluation of SLN‐Loaded Thermoresponsive Hydrogel System of Topotecan as Biological Macromolecule for Colorectal …

R Xing, O Mustapha, T Ali, M Rehman… - BioMed Research …, 2021 - Wiley Online Library
Background. Chemotherapeutic drugs cause severe toxicities if administered unprotected,
without proper targeting, and controlled release. In this study, we developed topotecan‐(TPT …

Nanotechnology based solutions for anti-leishmanial impediments: a detailed insight

H Jamshaid, FU Din, GM Khan - Journal of Nanobiotechnology, 2021 - Springer
As a neglected tropical disease, Leishmaniasis is significantly instigating morbidity and
mortality across the globe. Its clinical spectrum varies from ulcerative cutaneous lesions to …

Proniosomes derived niosomes: recent advancements in drug delivery and targeting

M Khatoon, KU Shah, FU Din, SU Shah… - Drug …, 2017 - Taylor & Francis
Vesicular drug delivery systems have gained wide attention in the field of nanotechnology.
Among them proniosomes become the superior over other vesicular carriers. Proniosomes …

Development, in-vitro and in-vivo evaluation of ezetimibe-loaded solid lipid nanoparticles and their comparison with marketed product

F ud Din, A Zeb, KU Shah - Journal of drug delivery science and …, 2019 - Elsevier
This study aims to develop ezetimibe-loaded solid lipid nanoparticles (SLNs) and compare
them with marketed product and drug suspension for dissolution and bioavailability …

Levosulpiride-loaded nanostructured lipid carriers for brain delivery with antipsychotic and antidepressant effects

S Maqsood, FU Din, SU Khan, E Elahi, Z Ali… - Life Sciences, 2022 - Elsevier
Aims Herein, we investigate the potential of levosulpiride-loaded nanostructured lipid
carriers (LEVO-NLCs) for effective brain delivery with anti-psychotic and antidepressant …

Self-emulsifying drug delivery systems (SEDDS): measuring energy dynamics to determine thermodynamic and kinetic stability

FU Rehman, A Farid, SU Shah, MJ Dar, AU Rehman… - Pharmaceuticals, 2022 - mdpi.com
This research was designed to identify thermodynamically and kinetically stable lipidic self-
emulsifying formulations through simple energy dynamics in addition to highlighting and …