BeAtMuSiC: prediction of changes in protein–protein binding affinity on mutations
The ability of proteins to establish highly selective interactions with a variety of (macro)
molecular partners is a crucial prerequisite to the realization of their biological functions. The …
molecular partners is a crucial prerequisite to the realization of their biological functions. The …
Protein–protein binding affinity prediction from amino acid sequence
K Yugandhar, MM Gromiha - Bioinformatics, 2014 - academic.oup.com
Motivation: Protein–protein interactions play crucial roles in many biological processes and
are responsible for smooth functioning of the machinery in living organisms. Predicting the …
are responsible for smooth functioning of the machinery in living organisms. Predicting the …
Computational approaches for predicting the binding sites and understanding the recognition mechanism of protein–DNA complexes
MM Gromiha, R Nagarajan - Advances in protein chemistry and structural …, 2013 - Elsevier
Protein–DNA recognition plays an important role in the regulation of gene expression.
Understanding the influence of specific residues for protein–DNA interactions and the …
Understanding the influence of specific residues for protein–DNA interactions and the …
Predicting the immune escape of SARS-CoV-2 neutralizing antibodies upon mutation
COVID-19 has resulted in millions of deaths and severe impact on economies worldwide.
Moreover, the emergence of SARS-CoV-2 variants presented significant challenges in …
Moreover, the emergence of SARS-CoV-2 variants presented significant challenges in …
Structural, energetic and lipophilic analysis of SARS-CoV-2 non-structural protein 9 (NSP9)
J de O. Araújo, S Pinheiro, WJ Zamora, CN Alves… - Scientific Reports, 2021 - nature.com
In SARS-CoV-2 replication complex, the Non-structural protein 9 (Nsp9) is an important RNA
binding subunit in the RNA-synthesizing machinery. The dimeric forms of coronavirus Nsp9 …
binding subunit in the RNA-synthesizing machinery. The dimeric forms of coronavirus Nsp9 …
Protein-protein interactions and prediction: a comprehensive overview
G Sowmya, S Ranganathan - Protein and peptide letters, 2014 - ingentaconnect.com
Molecular function in cellular processes is governed by protein-protein interactions (PPIs)
within biological networks. Selective yet specific association of these protein partners …
within biological networks. Selective yet specific association of these protein partners …
Elucidating important structural features for the binding affinity of spike‐SARS‐CoV‐2 neutralizing antibody complexes
Abstract The coronavirus disease 2019 (COVID‐19) has affected the lives of millions of
people around the world. In an effort to develop therapeutic interventions and control the …
people around the world. In an effort to develop therapeutic interventions and control the …
[HTML][HTML] Protein-protein interfaces are vdW dominant with selective H-bonds and (or) electrostatics towards broad functional specificity
Several catalysis, cellular regulation, immune function, cell wall assembly, transport,
signaling and inhibition occur through Protein-Protein Interactions (PPI). This is possible …
signaling and inhibition occur through Protein-Protein Interactions (PPI). This is possible …
Prediction of protein–protein interaction sites with machine-learning-based data-cleaning and post-filtering procedures
GH Liu, HB Shen, DJ Yu - The Journal of membrane biology, 2016 - Springer
Accurately predicting protein–protein interaction sites (PPIs) is currently a hot topic because
it has been demonstrated to be very useful for understanding disease mechanisms and …
it has been demonstrated to be very useful for understanding disease mechanisms and …
Understanding the molecular basis of MK2–p38α signaling complex assembly: insights into protein–protein interaction by molecular dynamics and free energy studies
Y Yang, H Liu, X Yao - Molecular BioSystems, 2012 - pubs.rsc.org
The formation of a p38 MAPK and MAPK-activated protein kinase 2 (MK2) signaling
complex is physiologically relevant to cellular responses such as the proinflammatory …
complex is physiologically relevant to cellular responses such as the proinflammatory …