An overview of clinical and commercial impact of drug delivery systems

AC Anselmo, S Mitragotri - Journal of Controlled Release, 2014 - Elsevier
Drug delivery systems are widely researched and developed to improve the delivery of
pharmaceutical compounds and molecules. The last few decades have seen a marked …

pH-Responsive carriers for oral drug delivery: challenges and opportunities of current platforms

L Liu, WD Yao, YF Rao, XY Lu, JQ Gao - Drug Delivery, 2017 - Taylor & Francis
Oral administration is a desirable alternative of parenteral administration due to the
convenience and increased compliance to patients, especially for chronic diseases that …

Hydrogels in biology and medicine: from molecular principles to bionanotechnology

NA Peppas, JZ Hilt, A Khademhosseini… - Advanced …, 2006 - Wiley Online Library
Hydrophilic polymers are the center of research emphasis in nanotechnology because of
their perceived “intelligence”. They can be used as thin films, scaffolds, or nanoparticles in a …

Oral insulin delivery platforms: strategies to address the biological barriers

Y Xiao, Z Tang, J Wang, C Liu, N Kong… - Angewandte Chemie …, 2020 - Wiley Online Library
Diabetes mellitus is a lifelong metabolic disease that requires frequent subcutaneous
injections of insulin. However, this method of administration can be associated with patient …

Hydrogels in emerging technologies for type 1 diabetes

S Fuchs, AU Ernst, LH Wang, K Shariati… - Chemical …, 2020 - ACS Publications
Type 1 diabetes therapies that afford tighter glycemic control in a more manageable and
painless manner for patients has remained a central focus of next-generation diabetes …

Biomaterials: where we have been and where we are going

BD Ratner, SJ Bryant - Annu. Rev. Biomed. Eng., 2004 - annualreviews.org
▪ Abstract Since its inception just over a half century ago, the field of biomaterials has seen a
consistent growth with a steady introduction of new ideas and productive branches. This …

Nanoparticles for drug delivery: the need for precision in reporting particle size parameters

M Gaumet, A Vargas, R Gurny, F Delie - European journal of …, 2008 - Elsevier
Polymeric drug-loaded nanoparticles have been extensively studied in the field of drug
delivery. Biodistribution depends on the physicochemical properties of particles, especially …

Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach

A des Rieux, V Fievez, M Garinot, YJ Schneider… - Journal of controlled …, 2006 - Elsevier
Peptides and proteins remain poorly bioavailable upon oral administration. One of the most
promising strategies to improve their oral delivery relies on their association with colloidal …

Therapeutic applications of hydrogels in oral drug delivery

LA Sharpe, AM Daily, SD Horava… - Expert opinion on drug …, 2014 - Taylor & Francis
Introduction: Oral delivery of therapeutics, particularly protein-based pharmaceutics, is of
great interest for safe and controlled drug delivery for patients. Hydrogels offer excellent …

Advances in biomaterials, drug delivery, and bionanotechnology

R Langer, NA Peppas - AIChE Journal, 2003 - Wiley Online Library
Biomaterials are widely used in numerous medical applications. Chemical engineering has
played a central role in this research and development. Polymers as biomaterials, materials …