Serological cross-reactivity among common flaviviruses
The Flavivirus genus is made up of viruses that are either mosquito-borne or tick-borne and
other viruses transmitted by unknown vectors. Flaviviruses present a significant threat to …
other viruses transmitted by unknown vectors. Flaviviruses present a significant threat to …
Protective and enhancing interactions among dengue viruses 1-4 and Zika virus
Dengue viruses 1-4 (DENV 1-4) and Zika virus (ZIKV) are closely related flaviviruses
transmitted by Aedes mosquitoes that co-circulate in Asia, the Americas, Africa, and …
transmitted by Aedes mosquitoes that co-circulate in Asia, the Americas, Africa, and …
Affinity-restricted memory B cells dominate recall responses to heterologous flaviviruses
Memory B cells (MBCs) can respond to heterologous antigens either by molding new
specificities through secondary germinal centers (GCs) or by selecting preexisting clones …
specificities through secondary germinal centers (GCs) or by selecting preexisting clones …
Integrated pipeline for the accelerated discovery of antiviral antibody therapeutics
P Gilchuk, RG Bombardi, JH Erasmus, Q Tan… - Nature biomedical …, 2020 - nature.com
The emergence and re-emergence of highly virulent viral pathogens with the potential to
cause a pandemic creates an urgent need for the accelerated discovery of antiviral …
cause a pandemic creates an urgent need for the accelerated discovery of antiviral …
Broad and potent neutralizing human antibodies to tick-borne flaviviruses protect mice from disease
M Agudelo, M Palus, JR Keeffe, F Bianchini… - Journal of Experimental …, 2021 - rupress.org
Tick-borne encephalitis virus (TBEV) is an emerging human pathogen that causes
potentially fatal disease with no specific treatment. Mouse monoclonal antibodies are …
potentially fatal disease with no specific treatment. Mouse monoclonal antibodies are …
Broadly neutralizing monoclonal antibodies protect against multiple tick-borne flaviviruses
Although Powassan virus (POWV) is an emerging tick-transmitted flavivirus that causes
severe or fatal neuroinvasive disease in humans, medical countermeasures have not yet …
severe or fatal neuroinvasive disease in humans, medical countermeasures have not yet …
Application of germline antibody features to vaccine development, antibody discovery, antibody optimization and disease diagnosis
Y Zhang, Q Li, L Luo, C Duan, J Shen, Z Wang - Biotechnology Advances, 2023 - Elsevier
Although the efficacy and commercial success of vaccines and therapeutic antibodies have
been tremendous, designing and discovering new drug candidates remains a labor-, time …
been tremendous, designing and discovering new drug candidates remains a labor-, time …
Landscape of monoclonal antibodies targeting zika and dengue: therapeutic solutions and critical insights for vaccine development
V Dussupt, K Modjarrad, SJ Krebs - Frontiers in immunology, 2021 - frontiersin.org
The unprecedented 2015–2016 Zika outbreak in the Americas sparked global concern and
drove the rapid deployment of vaccine and therapeutic countermeasures against this re …
drove the rapid deployment of vaccine and therapeutic countermeasures against this re …
Neutralizing antibodies to block viral entry and for identification of entry inhibitors
EH Tam, Y Peng, MXY Cheah, C Yan, T Xiao - Antiviral Research, 2024 - Elsevier
Neutralizing antibodies (NAbs) are naturally produced by our immune system to combat viral
infections. Clinically, neutralizing antibodies with potent efficacy and high specificity have …
infections. Clinically, neutralizing antibodies with potent efficacy and high specificity have …
Mapping the diverse structural landscape of the flavivirus antibody repertoire
Highlights•Flavivirus structures in complex with neutralizing antibodies are
analyzed.•Envelope (E) protein epitopes are mapped and classified based on structural …
analyzed.•Envelope (E) protein epitopes are mapped and classified based on structural …