This review summarizes the current knowledge on essential vitamins B1, B2, B3, and B5.
These B-complex vitamins must be taken from diet, with the exception of vitamin B3, that can …

Megasynthases, such as type I fatty acid and polyketide synthases (FASs and PKSs), are
multienzyme complexes responsible for producing primary metabolites and complex natural …

Fatty acid synthases (FASs) and polyketide synthases (PKSs) iteratively elongate and often
reduce two-carbon ketide units in de novo fatty acid and polyketide biosynthesis. Cycles of …

Modular polyketide synthases (PKSs) produce complex, bioactive secondary metabolites in
assembly line-like multistep reactions. Longstanding efforts to produce novel, biologically …

Tambjamine YP1 is a pyrrole-containing natural product. Analysis of the enzymes encoded
in the Pseudoalteromonas tunicata “tam” biosynthetic gene cluster (BGC) identified a unique …

Ketosynthases (KSs) catalyze carbon–carbon bond-forming reactions in fatty acid synthases
(FASs) and polyketide synthases (PKSs). KSs utilize a two-step ping-pong kinetic …

Elongating ketosynthases (KSs) catalyze carbon–carbon bond-forming reactions during the
committed step for each round of chain extension in both fatty acid synthases (FASs) and …

Megasynthasen wie die Typ I Fettsäuresynthasen (engl. fatty acid synthases, FASs) und
Polyketidsynthasen (PKSs) sind Multienzymkomplexe, die für die Produktion von primären …

Acyl-homoserine lactone synthases make specific AHL quorum sensing signals to aid
virulence in Gram-negative bacteria. Here, we use solution NMR spectroscopy to …

Type II polyketide synthases (PKSs) are protein assemblies, encoded by biosynthetic gene
clusters in microorganisms, that manufacture structurally complex and pharmacologically …