Alzheimer's disease (AD) is an age‐associated neurodegenerative disorder with
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …

Lipid droplets (LDs) are ubiquitous organelles that store and supply lipids for energy
metabolism, membrane synthesis and production of lipid-derived signaling molecules. While …

Astrocytes provide key neuronal support, and their phenotypic transformation is implicated in
neurodegenerative diseases. Metabolically, astrocytes possess low mitochondrial oxidative …

Alzheimer's disease, the most common age-related neurodegenerative disease, is
characterized by tau aggregation and associated with disrupted circadian rhythms and …

Lipid droplets (LDs) are the organelles for storing neutral lipids, which are broken down
when energy is insufficient. It has been suggested that excessive accumulation of LDs can …

Lipid droplets are highly dynamic intracellular organelles that store neutral lipids such as
cholesteryl esters and triacylglycerols. They have recently emerged as key stress response …

Neurodegenerative diseases (NDDs) are a series of disorders characterized by the
progressive loss of specific neurons, leading to cognitive and locomotor impairment. NDDs …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by alpha-synuclein
(αSyn) aggregation and associated with abnormalities in lipid metabolism. The …

The greatest risk factor for neurodegeneration is the aging of the multiple cell types of
human CNS, among which microglia are important because they are the “sentinels” of …

Simple Summary This review highlights the importance of perilipins in lipid metabolism and
their potential as therapeutic targets for lipid-associated diseases like cancer and obesity …