Although ischemic stroke is a major cause of morbidity and mortality, current therapies
benefit only a small proportion of patients. Transplantation of mesenchymal stromal cells …

2 Stroke May 2018 produce a host of angiogenic factors. 23–26 The enhancement of
endogenous neurogenesis stimulated by brain injury has been shown for mesenchymal …

Medium-sized spiny neurons (MSNs) are the only neostriatum projection neurons, and their
degeneration underlies some of the clinical features of Huntington's disease. Using …

Objective Amyotrophic lateral sclerosis (ALS) is the most severe disorder within the
spectrum of motor neuron diseases (MND) that has no effective treatment and a …

Retinitis pigmentosa (RP) is a group of inherited retinal disorders characterized by
progressive loss of photoreceptors and eventually leads to retina degeneration and atrophy …

Dynamic range limitations are challenging to proteomics, particularly in clinical samples.
Affinity proteomics partially overcomes this, yet suffers from dependence on reagent quality …

The role of secreted soluble factors in the modification of cellular responses is a recurrent
theme in the study of all tissues and systems. In an attempt to make straightforward the very …

Machado-Joseph disease (MJD) or spinocerebellar ataxia type 3, the most common
dominant spinocerebellar ataxia (SCA) worldwide, is caused by over-repetition of a CAG …

Because of unparalleled advantages over other cells, stem cells are widely used in genetic
diagnosis, drug delivery, and regenerative medicine. However, because the content of stem …

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a critical disease characterized by
debilitating pelvic pain associated with lower urinary tract symptoms. Effective therapeutic …