Liposomes for use in gene delivery

DA Balazs, WT Godbey - Journal of drug delivery, 2011 - Wiley Online Library
Liposomes have a wide array of uses that have been continuously expanded and improved
upon since first being observed to self‐assemble into vesicular structures. These …

DNA-based therapeutics and DNA delivery systems: a comprehensive review

SD Patil, DG Rhodes, DJ Burgess - The AAPS journal, 2005 - Springer
The past several years have witnessed the evolution of gene medicine from an experimental
technology into a viable strategy for developing therapeutics for a wide range of human …

p53 in neuronal apoptosis

C Culmsee, MP Mattson - Biochemical and biophysical research …, 2005 - Elsevier
The tumor suppressor and transcription factor p53 is a key modulator of cellular stress
responses, and activation of p53 can trigger apoptosis in many cell types including neurons …

The effect of the α2-agonist dexmedetomidine and the N-methyl-D-aspartate antagonist S (+)-ketamine on the expression of apoptosis-regulating proteins after …

K Engelhard, C Werner, E Eberspächer… - Anesthesia & …, 2003 - journals.lww.com
In this study, we investigated whether the neuroprotection previously seen with
dexmedetomidine or S (+)-ketamine involves regulation of proapoptotic (Bax and p53) and …

A review of different types of liposomes and their advancements as a form of gene therapy treatment for breast cancer

GYW Tseu, KA Kamaruzaman - Molecules, 2023 - mdpi.com
Breast cancer incidence and mortality rates have increased exponentially during the last
decade, particularly among female patients. Current therapies, including surgery and …

Drug delivery systems: past, present, and future

RM Mainardes, LP Silva - Current drug targets, 2004 - ingentaconnect.com
Drug delivery systems are essential components of drugs controlled release. In the last
decades, several drug delivery technologies have emerged including capsules, liposomes …

P53 mediates the apoptotic response to GTP depletion after renal ischemia-reperfusion: protective role of a p53 inhibitor

KJ Kelly, Z Plotkin, SL Vulgamott… - Journal of the American …, 2003 - journals.lww.com
Ischemic injury to the kidney is characterized in part by nucleotide depletion and tubular cell
death in the form of necrosis or apoptosis. GTP depletion was recently identified as an …

Techniques for gene transfer into neurons

P Washbourne, AK McAllister - Current opinion in neurobiology, 2002 - Elsevier
To illuminate the function of the thousands of genes that make up the complexity of the
nervous system, it is critical to be able to introduce and express DNA in neurons. Over the …

Pifithrin-α supresses p53 and protects cochlear and vestibular hair cells from cisplatin-induced apoptosis

M Zhang, W Liu, D Ding, R Salvi - Neuroscience, 2003 - Elsevier
Cisplatin, a commonly used antineoplastic agent, destroys the sensory hair cells in the
cochlear and vestibular system leading to irreversible hearing loss and balance problems …

Functionalized gold nanoparticles for applications in bionanotechnology

WR Glomm - Journal of Dispersion Science and Technology, 2005 - Taylor & Francis
Gold nanoparticles have unique optical and chemical properties that make them ideally
suited for a number of applications in bionanotechnology, including optical probes, targeted …