Cholangiocarcinoma (CCA) encompasses diverse epithelial tumors historically associated
with poor outcomes due to an aggressive disease course, late diagnosis, and limited benefit …

Highlights•New selective RET inhibitors have activity and favourable toxicity profiles in RET-
altered solid tumours.•There is a need to identify the optimal techniques to detect RET …

Background Cholangiocarcinoma (CCA) is a primary malignancy of the biliary tract with a
dismal prognosis. Recently, several actionable genetic aberrations were identified with …

Background Advanced cholangiocarcinoma has a poor prognosis. Molecular targeted
approaches have been proposed for patients after progression under first-line …

Biomarker testing is crucial for treatment selection in advanced non-small cell lung cancer
(NSCLC). However, the quantity of available tissue often presents a key constraint for …

Retiform and composite hemangioendotheliomas (CHEs) are both locally aggressive, rarely
metastasizing vascular neoplasms characterized by arborizing vascular channels lined by …

Immune checkpoint blockade (ICB) expands the therapeutic options for metastatic lung
cancer nowadays representing a standard frontline strategy as monotherapy or combination …

NTRK fusions involving three neurotrophic tyrosine receptor kinase genes NTRK1, NTRK2,
and NTRK3 and a variety of fusion partners were identified as oncogenic drivers across …

The genetic hallmark of epithelioid hemangioma (EH) is the presence of recurrent gene
fusions involving FOS and FOSB transcription factors, which occur in one-third of the cases …

Panel‐based methods are commonly employed for the analysis of novel gene fusions in
precision diagnostics and new drug development in cancer. However, these methods are …