The role of m6A/m-RNA methylation in stress response regulation

M Engel, C Eggert, PM Kaplick, M Eder, S Röh, L Tietze… - Neuron, 2018 - cell.com
Summary N 6-methyladenosine (m 6 A) and N 6, 2′-O-dimethyladenosine (m 6 Am) are
abundant mRNA modifications that regulate transcript processing and translation. The role …

Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin

D Wakhloo, F Scharkowski, Y Curto… - Nature …, 2020 - nature.com
Erythropoietin (EPO), named after its role in hematopoiesis, is also expressed in mammalian
brain. In clinical settings, recombinant EPO treatment has revealed a remarkable …

A neuronal PI(3,4,5)P3-dependent program of oligodendrocyte precursor recruitment and myelination

S Goebbels, GL Wieser, A Pieper, S Spitzer… - Nature …, 2017 - nature.com
The molecular trigger of CNS myelination is unknown. By targeting Pten in cerebellar
granule cells and activating the AKT1–mTOR pathway, we increased the caliber of normally …

[HTML][HTML] Dysregulated expression of neuregulin-1 by cortical pyramidal neurons disrupts synaptic plasticity

A Agarwal, M Zhang, I Trembak-Duff… - Cell reports, 2014 - cell.com
Summary Neuregulin-1 (NRG1) gene variants are associated with increased genetic risk for
schizophrenia. It is unclear whether risk haplotypes cause elevated or decreased …

Serotonin receptor 2c-expressing cells in the ventral CA1 control attention via innervation of the Edinger–Westphal nucleus

X Li, W Chen, K Pan, H Li, P Pang, Y Guo, S Shu… - Nature …, 2018 - nature.com
The hippocampus is divided into dorsal and ventral zones along its principal axis. The
dorsal hippocampus is critical for learning and memory, yet the basic function of the ventral …

Neuronal basic helix–loop–helix proteins Neurod2/6 regulate cortical commissure formation before midline interactions

I Bormuth, K Yan, T Yonemasu, M Gummert… - Journal of …, 2013 - Soc Neuroscience
Establishment of long-range fiber tracts by neocortical projection neurons is fundamental for
higher brain functions. The molecular control of axon tract formation, however, is still poorly …

Subcellular sorting of neuregulins controls the assembly of excitatory-inhibitory cortical circuits

D Exposito-Alonso, C Osorio, C Bernard… - Elife, 2020 - elifesciences.org
The assembly of specific neuronal circuits relies on the expression of complementary
molecular programs in presynaptic and postsynaptic neurons. In the cerebral cortex, the …

Hippocampal neurons with stable excitatory connectivity become part of neuronal representations

TP Castello-Waldow, G Weston, AF Ulivi… - PLoS …, 2020 - journals.plos.org
Experiences are represented in the brain by patterns of neuronal activity. Ensembles of
neurons representing experience undergo activity-dependent plasticity and are important for …

Autoantibodies against NMDA receptor 1 modify rather than cause encephalitis

JBH Wilke, M Hindermann, SA Berghoff, S Zihsler… - Molecular …, 2021 - nature.com
The etiology and pathogenesis of “anti-N-methyl-D-aspartate-receptor (NMDAR)
encephalitis” and the role of autoantibodies (AB) in this condition are still obscure. While …

Neurocan inhibits semaphorin 3F induced dendritic spine remodeling through NrCAM in cortical neurons

V Mohan, EV Wyatt, I Gotthard, KD Phend… - Frontiers in Cellular …, 2018 - frontiersin.org
Neurocan is a chondroitin sulfate proteoglycan present in perineuronal nets, which are
associated with closure of the critical period of synaptic plasticity. During postnatal …