Stimulus-induced nuclear factor-κB (NF-κB) activity, the central mediator of inflammatory
responses and immune function, comprises a family of dimeric transcription factors that …

Cancer is now appreciated as not only a highly heterogenous pathology with respect to cell
type and tissue origin but also as a disease involving dysregulation of multiple pathways …

Crosstalk and complexity within signaling pathways and their perturbation by oncogenes
limit component-by-component approaches to understanding human disease. Network …

Immunoblotting (also known as Western blotting) combined with digital image analysis can
be a reliable method for analyzing the abundance of proteins and protein modifications, but …

Large‐scale protein signalling networks are useful for exploring complex biochemical
pathways but do not reveal how pathways respond to specific stimuli. Such specificity is …

Signal transduction pathways control cellular responses to stimuli, but it is unclear how
molecular information is processed as a network. We constructed a systems model of 7980 …

New technologies are permitting large-scale quantitative studies of signal-transduction
networks. Such data are hard to understand completely by inspection and intuition.'Data …

When exposed to tumor necrosis factor (TNF) or TNF-related apoptosis-inducing ligand
(TRAIL), a closely related death ligand and investigational therapeutic, cells enter a …

MSC can act as a pluripotent source of reparative cells during injury and therefore have
great potential in regenerative medicine and tissue engineering. However, the response of …

Although human epidermal growth factor receptor 2 (HER2) overexpression is implicated in
tumor progression for a variety of cancer types, how it dysregulates signaling networks …