Advances in the development of small molecule antivirals against equine encephalitic viruses
TJ Ogorek, JE Golden - Viruses, 2023 - mdpi.com
Venezuelan, western, and eastern equine encephalitic alphaviruses (VEEV, WEEV, and
EEEV, respectively) are arboviruses that are highly pathogenic to equines and cause …
EEEV, respectively) are arboviruses that are highly pathogenic to equines and cause …
Deciphering the role of protein phosphatases in apicomplexa: the future of innovative therapeutics?
A Fréville, B Gnangnon, AS Khelifa, M Gissot, J Khalife… - Microorganisms, 2022 - mdpi.com
Parasites belonging to the Apicomplexa phylum still represent a major public health and
world-wide socioeconomic burden that is greatly amplified by the spread of resistances …
world-wide socioeconomic burden that is greatly amplified by the spread of resistances …
Protein phosphatase 1α interacts with venezuelan equine encephalitis virus capsid protein and regulates viral replication through modulation of capsid …
ABSTRACT Protein phosphatase 1 (PP1) is a serine/threonine phosphatase which has
been implicated in the regulation of a number of viruses, including HIV-1, Ebolavirus, and …
been implicated in the regulation of a number of viruses, including HIV-1, Ebolavirus, and …
Targeting the non-catalytic RVxF site of protein phosphatase-1 with small molecules for Ebola virus inhibition
Ebola virus (EBOV) is a non-segmented negative-sense RNA virus that causes a severe
human disease. The ongoing EBOV outbreak in the Eastern part of Democratic Republic of …
human disease. The ongoing EBOV outbreak in the Eastern part of Democratic Republic of …
HIV-1 Transcription Inhibitor 1E7-03 Decreases Nucleophosmin Phosphorylation
Transcription activation of latent human immunodeficiency virus-1 (HIV-1) occurs due to HIV-
1 rebound, the interruption of combination antiretroviral therapy, or development of drug …
1 rebound, the interruption of combination antiretroviral therapy, or development of drug …
Protein phosphatase 1–targeting small-molecule C31 inhibits Ebola virus replication
T Ammosova, CA Pietzsch, Y Saygideğer… - The Journal of …, 2018 - academic.oup.com
Background Ebola virus (EBOV) infection causes severe hemorrhagic fever. EBOV
transcription is controlled by host protein phosphatase 1 (PP1), which dephosphorylates …
transcription is controlled by host protein phosphatase 1 (PP1), which dephosphorylates …
Differences in transcriptional dynamics between T-cells and macrophages as determined by a three-state mathematical model
C DeMarino, M Cowen, ML Pleet, DO Pinto… - Scientific reports, 2020 - nature.com
HIV-1 viral transcription persists in patients despite antiretroviral treatment, potentially due to
intermittent HIV-1 LTR activation. While several mathematical models have been explored in …
intermittent HIV-1 LTR activation. While several mathematical models have been explored in …
Structural Optimization of 2,3-Dihydro-1H-cyclopenta[b]quinolines Targeting the Noncatalytic RVxF Site of Protein Phosphatase 1 for HIV-1 Inhibition
Combination antiretroviral therapy (cART) suppresses human immunodeficiency virus-1
(HIV-1) replication but is unable to permanently eradicate HIV-1. Importantly, cART does not …
(HIV-1) replication but is unable to permanently eradicate HIV-1. Importantly, cART does not …
HIV-1 transcription inhibitor 1E7-03 restores LPS-induced alteration of lung leukocytes' infiltration dynamics and resolves inflammation in HIV transgenic mice
M Jerebtsova, A Ahmad, X Niu, O Rutagarama… - Viruses, 2020 - mdpi.com
Human immunodeficiency virus (HIV)-infected individuals treated with anti-retroviral therapy
often develop chronic non-infectious lung disease. To determine the mechanism of HIV-1 …
often develop chronic non-infectious lung disease. To determine the mechanism of HIV-1 …
[HTML][HTML] Ebola Virus NP Binding to Host Protein Phosphatase-1 Regulates Capsid Formation
A Ahmad, B Tigabu, A Ivanov, M Jerebtsova… - Research …, 2023 - ncbi.nlm.nih.gov
The Ebola virus (EBOV) transcriptional regulation involves host protein phosphatases PP1
and PP2A, which dephosphorylate the transcriptional cofactor of EBOV polymerase VP30 …
and PP2A, which dephosphorylate the transcriptional cofactor of EBOV polymerase VP30 …