Background Type 1 diabetes mellitus (T1DM) is an autoimmune disorder characterized by T
cell-mediated self-destruction of insulin-secreting islet β cells. Management of T1DM is …

Type 1 diabetes mellitus (T1DM) is an autoimmune disease that attacks pancreatic β-cells,
leading to the destruction of insulitis-related islet β-cells. Islet β-cell transplantation has been …

Background. To test the angiogenesis-promoting effects of bone marrow cells when
cotransplanted with islets. Methods. Streptozotocin-induced diabetic BALB/c mice were …

Autoimmune diseases are incurable. We have hypothesized that these diseases can be
cured by the transplantation of bone marrow (BM) stem cells that have been genetically …

Despite the increasing knowledge of pathophysiological mechanisms underlying the onset
of type 1 diabetes (T1D), the quest for therapeutic options capable of delaying/reverting the …

Experimental autoimmune encephalomyelitis (EAE) constitutes a paradigm of antigen (Ag)-
specific T cell driven autoimmune diseases. In this study, we transferred bone marrow cells …

Memory T cells develop early during the preclinical stages of autoimmune diseases and
have traditionally been considered resistant to tolerance induction. As such, they may …

Progress in gene therapy has produced promising results that translate experimental
research into clinical treatment. Gene modification has been extensively employed in cell …

The autoimmune regulator (AIRE) promotes “promiscuous” expression of tissue‐restricted
antigens (TRA) in thymic medullary epithelial cells to facilitate thymic deletion of autoreactive …

Based on the principle that immune ablation followed by HSC-mediated recovery purges
disease-causing leukocytes to interrupt autoimmune disease progression, hematopoietic …