Tissue engineering is considered one of the most important therapeutic strategies of
regenerative medicine. The main objective of these new technologies is the development of …

Osteoarthritis results in irreparable loss of articular cartilage. Due to its avascular nature and
low mitotic activity, cartilage has little intrinsic capacity for repair. Cartilage loss leads to pain …

Distinctive characteristics of articular cartilage such as avascularity and low chondrocyte
conversion rate present numerous challenges for orthopedists. Tissue engineering is a …

Articular cartilage defects caused by injury frequently lead to osteoarthritis, a painful and
costly disease. Despite widely used surgical methods to treat articular cartilage defects and …

The drive to develop cartilage implants for the treatment of major defects in the
musculoskeletal system has resulted in a major research thrust towards developing …

Poor regenerative potential of cartilage tissue due to the avascular nature and lack of
supplementation of reparative cells impose an important challenge in recent medical …

Cartilage repair remains a major challenge in human orthopedic medicine, necessitating the
application of innovative strategies to overcome existing technical and clinical limitations …

Osteochondral lesions (OCs) are typically of traumatic origins but are also caused by
degenerative conditions, in primis osteoarthritis (OA). On the other side, OC lesions …

The microenvironment plays a crucial role in stem cell differentiation, and a scaffold that
mimics native cartilaginous extracellular components can promote chondrogenesis. In this …

Scaffold geometry is known a biophysical spatial cue to modulate stem cell fate. However,
the effect of regulating topography on the chondrogenic differentiation of adipose-derived …