The focus of this review is to provide an overview of the current state of knowledge of
molecular mechanisms/processes that control differentiation of vascular smooth muscle cells …

The vascular smooth muscle cell (SMC) in adult animals is a highly specialized cell whose
principal function is contraction. However, this cell displays remarkable plasticity and can …

Serum response factor (SRF) regulates transcription of numerous muscle and growth factor-
inducible genes. Because SRF is not muscle specific, it has been postulated to activate …

Serum response factor (SRF) is a widely expressed transcription factor involved in
orchestrating disparate programs of gene expression linked to muscle differentiation and …

In all organisms, correct development, growth and function depends on the precise and
integrated control of the expression of their genes. Often, gene regulation depends upon the …

The transforming-growth-factor-β-activated kinase TAK1 is a member of the mitogen-
activated protein kinase kinase kinase family, which couples extracellular stimuli to gene …

Following gastrulation and establishment of the three embryonic germ layers, the first
definitive organ to form in the embryo is the heart, whose morphogenesis, growth, and …

The transcription factor serum response factor (SRF), a phylogenetically conserved nuclear
protein, mediates the rapid transcriptional response to extracellular stimuli, eg growth and …

Serum response factor (SRF) controls the transcription of muscle genes by recruiting a
variety of partner proteins, including members of the myocardin family of transcriptional …

The goal of the present study was to determine the molecular mechanism whereby
transforming growth factor β (TGFβ) increases smooth muscle (SM) α-actin expression …