Studies examining the inheritance of inflammatory bowel disease (IBD) within different
family groups have been the basis for recent molecular advances in the genetics of IBD. The …

B-cell-targeted therapy for autoimmune disease emerged from theoretical proposition to
practical reality between 1997 and 1998, with the availability of the B-cell-depleting …

In recent years, investigators have readdressed the complex issues involved in the
classification of inflammatory bowel diseases. In 2003, a Working Party of investigators with …

Toll-like receptors (TLR) and NOD2 are emerging as key mediators of innate host defence in
the intestinal mucosa, crucially involved in maintaining mucosal as well as commensal …

Inflammatory bowel disease (IBD) is the chronic inflammation of the gastrointestinal tract.
Recently, studies of the interplay between the adaptive and innate immune responses have …

Crohn's disease (CD) is characterized by patchy transmural inflammation involving any part
of the intestinal tract. Animal models have provided a great deal of insight into the …

The chronic inflammatory bowel diseases Crohn's disease and ulcerative colitis are
common causes of gastrointestinal disease in northern Europe, affecting as many as one in …

Background Inflammatory bowel diseases (IBD) result from an interaction between genetic
and environmental factors. Preliminary findings suggest that susceptibility genes differ …

Background and Aim A north-south gradient in inflammatory bowel disease (IBD) incidence
has been found in Europe and the United States. Its existence is inferred from comparisons …

Crohn's disease (CD) is an inflammatory bowel disease (IBD) with repeated remissions and
relapses. As the disease progresses, fibrosis and narrowing of the intestine occur, leading to …