Over the past 16 years, genetic code expansion and reprogramming in living organisms has
been transformed by advances that leverage the unique properties of pyrrolysyl-tRNA …

The modification of proteins with non‐protein entities is important for a wealth of
applications, and methods for chemically modifying proteins attract considerable attention …

Over the last decade, the ability to genetically encode unnatural amino acids (UAAs) has
evolved rapidly. The programmed incorporation of UAAs into recombinant proteins relies on …

Chemical modification of proteins is an important tool for probing natural systems, creating
therapeutic conjugates and generating novel protein constructs. Site-selective reactions …

The genetic incorporation of the 22nd proteinogenic amino acid, pyrrolysine (Pyl) at amber
codon is achieved by the action of pyrrolysyl-tRNA synthetase (PylRS) together with its …

1. INTRODUCTION In eukaryotic cells, inheritable information is stored in a nucleoprotein
complex referred to as chromatin. 1 This genome architecture serves two key purposes. On …

Highlights•Dha in proteins is easily and flexibly accessible under mild conditions.•Dha
reactivity is used in β, γ-C–S/Se/N/C bond-formation and allows 'zero scar'protein …

Organoselenium chemistry has proven to be a powerful tool for organic synthesis over
several decades. Nevertheless, the use of selenating reagents has often been limited by a …

The site-selective modification of peptide backbones allows an outstanding fine-tuning of
peptide conformation, folding ability, and physico-chemical and biological properties …

α, β-Dehydroamino acids (dhAAs) are noncanonical amino acids that are found in a wide
array of natural products and can be easily installed into peptides and proteins. dhAAs …