Background Autophagy is an intracellular degradation system that removes unnecessary or
dysfunctional components and recycles them for other cellular functions. Over the years, a …

Triple-negative breast cancer (TNBC) is well-known as the most aggressive subtype of
breast cancer. Because TNBC does not express Her2, estrogen receptor, and progesterone …

Progress in ovarian cancer treatment lags behind other tumor types. With diagnosis usually
at an advanced stage, there is a high demand for reliable prognostic biomarkers capable of …

Metabolic reprogramming is a hallmark of cancer. However, it is not well known how
metabolism affects cancer progression. We identified that metabolic enzyme acyl-CoA …

Colorectal cancer (CRC) is the third most commonly diagnosed malignancy and major
cause of cancer death in the world. Ferroptosis is a recently identified type of regulated cell …

Abstract Dysfunction of Sirtuin 3 (SIRT3), an NAD+-dependent histone deacetylase, impairs
varied mitochondrial metabolic pathways in human cancer. Here, we explored suppressive …

Abstract Background Tyrosine kinase inhibitors (TKIs) that specifically target mutational
points in the EGFR gene have significantly reduced suffering and provided greater relief to …

Ultrasound (US)-mediated sonodynamic therapy (SDT) has emerged as a spatiotemporally
controllable therapeutic modality in combating cancer because of its high tissue-penetration …

Defining drivers of tumour initiation can provide opportunities to control cancer progression.
Here we report that lysophosphatidic acid receptor 4 (LPAR4) becomes transiently …

Simple Summary Proteolytic enzymes, such as matrix metalloproteinases, plasminogen
activators and cathepsins, as well as non-proteolytic enzymatic partners, such as …