Mechanism and applications of CRISPR/Cas-9-mediated genome editing
M Asmamaw, B Zawdie - Biologics: targets and therapy, 2021 - Taylor & Francis
Clustered regularly interspaced short palindromic repeat (CRISPR) and their associated
protein (Cas-9) is the most effective, efficient, and accurate method of genome editing tool in …
protein (Cas-9) is the most effective, efficient, and accurate method of genome editing tool in …
Novel CRISPR–Cas systems: an updated review of the current achievements, applications, and future research perspectives
According to Darwin's theory, endless evolution leads to a revolution. One such example is
the Clustered Regularly Interspaced Palindromic Repeats (CRISPR)–Cas system, an …
the Clustered Regularly Interspaced Palindromic Repeats (CRISPR)–Cas system, an …
Highly efficient CD4+ T cell targeting and genetic recombination using engineered CD4+ cell-homing mRNA-LNPs
I Tombácz, D Laczkó, H Shahnawaz, H Muramatsu… - Molecular Therapy, 2021 - cell.com
Nucleoside-modified messenger RNA (mRNA)-lipid nanoparticles (LNPs) are the basis for
the first two EUA (Emergency Use Authorization) COVID-19 vaccines. The use of nucleoside …
the first two EUA (Emergency Use Authorization) COVID-19 vaccines. The use of nucleoside …
Gene editing and CRISPR in the clinic: current and future perspectives
Genome editing technologies, particularly those based on zinc-finger nucleases (ZFNs),
transcription activator-like effector nucleases (TALENs), and CRISPR (clustered regularly …
transcription activator-like effector nucleases (TALENs), and CRISPR (clustered regularly …
CRISPR/Cas gene therapy
B Zhang - Journal of cellular physiology, 2021 - Wiley Online Library
Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐associated
enzyme (Cas) is a naturally occurring genome editing tool adopted from the prokaryotic …
enzyme (Cas) is a naturally occurring genome editing tool adopted from the prokaryotic …
Towards application of CRISPR-Cas12a in the design of modern viral DNA detection tools
J Dronina, U Samukaite-Bubniene… - Journal of …, 2022 - Springer
Early detection of viral pathogens by DNA-sensors in clinical samples, contaminated foods,
soil or water can dramatically improve clinical outcomes and reduce the socioeconomic …
soil or water can dramatically improve clinical outcomes and reduce the socioeconomic …
Application of CRISPR/Cas9-based gene editing in HIV-1/AIDS therapy
Q Xiao, D Guo, S Chen - Frontiers in cellular and infection …, 2019 - frontiersin.org
Despite the fact that great efforts have been made in the prevention and therapy of HIV-1
infection, HIV-1/AIDS remains a major threat to global human health. Highly active …
infection, HIV-1/AIDS remains a major threat to global human health. Highly active …
Genetic engineering of T cells for immunotherapy
Genetically engineered T cell immunotherapies have provided remarkable clinical success
to treat B cell acute lymphoblastic leukaemia by harnessing a patient's own T cells to kill …
to treat B cell acute lymphoblastic leukaemia by harnessing a patient's own T cells to kill …
Involvement of CXCR4 in normal and abnormal development
N Kawaguchi, TT Zhang, T Nakanishi - Cells, 2019 - mdpi.com
CXC motif chemokine receptor type 4 (CXCR4) is associated with normal and abnormal
development, including oncogenesis. The ligand of CXCR4 is stromal cell-derived factor …
development, including oncogenesis. The ligand of CXCR4 is stromal cell-derived factor …
CCR5-edited CD4+ T cells augment HIV-specific immunity to enable post-rebound control of HIV replication
Background We conducted a phase I clinical trial that infused CCR5 gene–edited CD4+ T
cells to determine how these T cells can better enable HIV cure strategies. Methods The aim …
cells to determine how these T cells can better enable HIV cure strategies. Methods The aim …