Abstract Alzheimer's disease (AD), characterized by the β-amyloid protein (Aβ) deposition
and tau hyperphosphorylation, is the most common dementia with uncertain etiology. The …

As the median age of the population increases, the number of individuals with Alzheimer's
disease (AD) and the associated socio-economic burden are predicted to worsen. While …

Alzheimer's disease (AD) is an irreversible, age-related progressive neurological disorder,
and the most common type of dementia in aged people. Neuropathological lesions of AD …

Copper is a trace element present in all tissues and is required for cellular respiration,
peptide amidation, neurotransmitter biosynthesis, pigment formation, and connective tissue …

Introduction: Demyelinating diseases of the central nervous system (CNS) comprise a group
of neurological disorders characterized by progressive (and eventually irreversible) loss of …

Industrialized societies produce many convenience foods with aluminum additives that
enhance various food properties and use alum (aluminum sulfate or aluminum potassium …

Metals are commonly found in the environment, household, and workplaces in various
forms, and a significant segment of the population is routinely exposed to the trace amount …

Oxidative stress, disrupted copper homeostasis, and neuroinflammation due to
overproduction of proinflammatory cytokines are considered leading causative factors in …

Neurodegenerative disorders are featured by a variety of pathological conditions that share
similar critical processes, such as oxidative stress, free radical activity, proteinaceous …

The cuprizone (CPZ) model allows the study of the biochemical processes underlying
nonautoimmune-mediated demyelination, remyelination, and chronic white matter disease …