Melatonin as a hormone: new physiological and clinical insights

J Cipolla-Neto, FG Amaral - Endocrine reviews, 2018 - academic.oup.com
Melatonin is a ubiquitous molecule present in almost every live being from bacteria to
humans. In vertebrates, besides being produced in peripheral tissues and acting as an …

Melatonin membrane receptors in peripheral tissues: distribution and functions

RM Slominski, RJ Reiter… - Molecular and cellular …, 2012 - Elsevier
Many of melatonin's actions are mediated through interaction with the G-protein coupled
membrane bound melatonin receptors type 1 and type 2 (MT1 and MT2, respectively) or …

Virtual discovery of melatonin receptor ligands to modulate circadian rhythms

RM Stein, HJ Kang, JD McCorvy, GC Glatfelter… - Nature, 2020 - nature.com
The neuromodulator melatonin synchronizes circadian rhythms and related physiological
functions through the actions of two G-protein-coupled receptors: MT1 and MT2. Circadian …

Melatonin receptors: molecular pharmacology and signalling in the context of system bias

E Cecon, A Oishi, R Jockers - British journal of pharmacology, 2018 - Wiley Online Library
Melatonin, N‐acetyl‐5‐methoxytryptamine, an evolutionally old molecule, is produced by the
pineal gland in vertebrates, and it binds with high affinity to melatonin receptors, which are …

Melatonin: a multitasking molecule

RJ Reiter, DX Tan, L Fuentes-Broto - Progress in brain research, 2010 - Elsevier
Abstract Melatonin (N-acetyl-5-methoxytryptamine) has revealed itself as an ubiquitously
distributed and functionally diverse molecule. The mechanisms that control its synthesis …

Melatonin: Nature's most versatile biological signal?

SR Pandi‐Perumal, V Srinivasan… - The FEBS …, 2006 - Wiley Online Library
Melatonin is a ubiquitous molecule and widely distributed in nature, with functional activity
occurring in unicellular organisms, plants, fungi and animals. In most vertebrates, including …

Functional MT1 and MT2 melatonin receptors in mammals

ML Dubocovich, M Markowska - Endocrine, 2005 - Springer
Melatonin, dubbed the hormone of darkness, is known to regulate a wide variety of
physiological processes in mammals. This review describes well-defined functional …

[HTML][HTML] Melatonin and the ovary: physiological and pathophysiological implications

H Tamura, Y Nakamura, A Korkmaz, LC Manchester… - Fertility and sterility, 2009 - Elsevier
OBJECTIVE: To summarize the role of melatonin in the physiology and pathophysiology of
the ovary. DESIGN: Review of literature. SETTING: University Health Science Center …

Melatonin receptors: role on sleep and circadian rhythm regulation

ML Dubocovich - Sleep medicine, 2007 - Elsevier
The circadian release of the hormone melatonin is regulated by the suprachiasmatic
nucleus (SCN), which feeds back into the nucleus to modulate sleep and circadian phase …

Melatonin as a free radical scavenger in the ovarian follicle

H Tamura, A Takasaki, T Taketani, M Tanabe… - Endocrine …, 2013 - jstage.jst.go.jp
This review summarizes new findings related to beneficial effects of melatonin (N-acetyl-5-
methoxytryptamine) on reproductive physiology. Recently many researchers have begun to …