Harnessing the immune system in glioblastoma
NF Brown, TJ Carter, D Ottaviani… - British journal of cancer, 2018 - nature.com
Glioblastoma is the most common primary malignant brain tumour. Survival is poor and
improved treatment options are urgently needed. Although immunotherapies have emerged …
improved treatment options are urgently needed. Although immunotherapies have emerged …
Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: from pathophysiology to treatment
GJ Yoshida - Journal of hematology & oncology, 2017 - Springer
Abstract The 2016 Nobel Prize in Physiology or Medicine was awarded to the researcher
that discovered autophagy, which is an evolutionally conserved catabolic process which …
that discovered autophagy, which is an evolutionally conserved catabolic process which …
EMT‐and MET‐related processes in nonepithelial tumors: importance for disease progression, prognosis, and therapeutic opportunities
The epithelial‐to mesenchymal (EMT) process is increasingly recognized for playing a key
role in the progression, dissemination, and therapy resistance of epithelial tumors …
role in the progression, dissemination, and therapy resistance of epithelial tumors …
Transient and stable vector transfection: Pitfalls, off-target effects, artifacts
AA Stepanenko, HH Heng - Mutation Research/Reviews in Mutation …, 2017 - Elsevier
Transient and stable vector transfections have played important roles in illustrating the
function of specific genes/proteins. The general assumption is that such a platform could …
function of specific genes/proteins. The general assumption is that such a platform could …
In vitro and in vivo enhancement of temozolomide effect in human glioblastoma by non-invasive application of cold atmospheric plasma
Simple Summary Glioblastoma (GBM) is an aggressive type of brain cancer, with which only
25% of patients survive for more than one year. Treatment of GBM has remained a …
25% of patients survive for more than one year. Treatment of GBM has remained a …
Tumor microenvironment in glioma invasion
S Tamai, T Ichinose, T Tsutsui, S Tanaka, F Garaeva… - Brain Sciences, 2022 - mdpi.com
A major malignant trait of gliomas is their remarkable infiltration capacity. When glioma
develops, the tumor cells have already reached the distant part. Therefore, complete …
develops, the tumor cells have already reached the distant part. Therefore, complete …
Signal transduction pathways and resistance to targeted therapies in glioma
A Tomiyama, K Ichimura - Seminars in cancer biology, 2019 - Elsevier
Although surgical techniques and adjuvant therapies have undergone progressive
development for decades, the therapeutic outcomes for treating glioblastoma (GBM) remain …
development for decades, the therapeutic outcomes for treating glioblastoma (GBM) remain …
The need for paradigm shift: prognostic significance and implications of standard therapy-related systemic immunosuppression in glioblastoma for immunotherapy …
AA Stepanenko, AO Sosnovtseva, MP Valikhov… - Frontiers in …, 2024 - frontiersin.org
Despite significant advances in our knowledge regarding the genetics and molecular
biology of gliomas over the past two decades and hundreds of clinical trials, no effective …
biology of gliomas over the past two decades and hundreds of clinical trials, no effective …
[HTML][HTML] Investigating the role of Hedgehog/GLI1 signaling in glioblastoma cell response to temozolomide
Resistance to chemotherapy substantially hinders successful glioblastoma (GBM) treatment,
contributing to an almost 100% mortality rate. Resistance to the frontline chemotherapy …
contributing to an almost 100% mortality rate. Resistance to the frontline chemotherapy …
Tubastatin A, an inhibitor of HDAC6, enhances temozolomide‑induced apoptosis and reverses the malignant phenotype of glioblastoma cells
A Urdiciain, E Erausquin… - International …, 2019 - spandidos-publications.com
Glioblastoma or grade IV astrocytoma is the most common and lethal form of glioma. Current
glioblastoma treatment strategies use surgery followed by chemotherapy with …
glioblastoma treatment strategies use surgery followed by chemotherapy with …