Simple Summary AML is a heterogenous malignancy with a variety of underlying genomic
abnormalities. Some of the genetic aberrations in AML have led to the development of …

Amplification of pro-oncogenic kinases is a common genetic alteration driving tumorigenic
phenotypes. Cancer cells rely on the amplified kinases to sustain cell proliferation, survival …

Human kinases play essential and diverse roles in the cellular activities of maintaining
homeostasis and growth. Genetic mutations in the genes encoding the kinases (or …

BACKGROUND Esophageal cancer is one of the most common malignant tumors of the
digestive system, with a 5-year survival rate of 15% to 50%. Cuproptosis, a unique kind of …

Breast cancer is still the largest cause of cancer death in women, and around 70% of
primary breast cancer patients are estrogen receptor (ER)-positive, which is the most …

Protein kinases are key regulators of cell signaling and have been important therapeutic
targets for three decades. ATP-competitive drugs directly inhibit the activity of kinases but …

The arrival of precision oncology is challenging the evidence standards under which
technologies are evaluated for regulatory approval as well as for health technology …

Phycocyanin, a pigment-protein found in Spirulina, has been shown to have powerful
biological properties. We developed a computational Petra/Osiris/Molinspiration/Density …

Background Pim-1 is overexpressed in cancer tissues and plays a vital role in
carcinogenesis. However, its clinical significance in cancers is not fully verified by meta …

Protein kinases play a pivotal role in signal transduction, protein synthesis, cell growth and
proliferation. Their deregulation represents the basis of pathogenesis for numerous …