Myocardial infarction is a prevalent major cardiovascular event that arises from myocardial
ischemia with or without reperfusion, and basic and translational research is needed to …

The response of immune cells in cardiac injury is divided into three continuous phases:
inflammation, proliferation and maturation. The kinetics of the inflammatory and proliferation …

Despite significant improvements in reperfusion strategies, acute coronary syndromes all too
often culminate in a myocardial infarction (MI). The consequent MI can, in turn, lead to …

Once myocardium dies during a heart attack, it is replaced by scar tissue over the course of
several weeks. The size, location, composition, structure and mechanical properties of the …

Adult humans fail to regenerate their hearts following injury, and this failure to regenerate
myocardium is a leading cause of heart failure and death worldwide. Although all adult …

Abstract Indoleamine 2, 3 dioxygenase-1 (IDO1) catalyzes tryptophan-kynurenine
metabolism in many inflammatory and cancer diseases. Of note, acute inflammation that …

Rationale: In response to injury, the rodent heart is capable of virtually full regeneration via
cardiomyocyte proliferation early in life. This regenerative capacity, however, is diminished …

During development, cardiogenesis is orchestrated by a family of heart progenitors that build
distinct regions of the heart. Each region contains diverse cell types that assemble to form …

Adult mammals undergo minimal regeneration following cardiac injury, which severely
compromises cardiac function and contributes to the ongoing burden of heart failure. In …

Astrocyte swelling occurs after central nervous system injury and contributes to brain
swelling, which can increase mortality. Mechanisms proffered to explain astrocyte swelling …