3D electron diffraction for chemical analysis: Instrumentation developments and innovative applications

T Gruene, E Mugnaioli - Chemical Reviews, 2021 - ACS Publications
In the past few years, many exciting papers reported results based on crystal structure
determination by electron diffraction. The aim of this review is to provide general and …

Electron diffraction of 3D molecular crystals

A Saha, SS Nia, JA Rodríguez - Chemical Reviews, 2022 - ACS Publications
Electron crystallography has a storied history which rivals that of its more established X-ray-
enabled counterpart. Recent advances in data collection and analysis have sparked a …

Molecular basis of Mg2+ permeation through the human mitochondrial Mrs2 channel

M Li, Y Li, Y Lu, J Li, X Lu, Y Ren, T Wen… - Nature …, 2023 - nature.com
Abstract Mitochondrial RNA splicing 2 (Mrs2), a eukaryotic CorA ortholog, enables Mg2+ to
permeate the inner mitochondrial membrane and plays an important role in mitochondrial …

Double-helix supramolecular nanofibers assembled from negatively curved nanographenes

K Kato, K Takaba, S Maki-Yonekura… - Journal of the …, 2021 - ACS Publications
The layered structures of graphite and related nanographene molecules play key roles in
their physical and electronic functions. However, the stacking modes of negatively curved …

Structural resolution of a small organic molecule by serial X-ray free-electron laser and electron crystallography

K Takaba, S Maki-Yonekura, I Inoue, K Tono… - Nature …, 2023 - nature.com
Abstract Structure analysis of small crystals is important in areas ranging from synthetic
organic chemistry to pharmaceutical and material sciences, as many compounds do not …

Emerging disordered layered-herringbone phase in organic semiconductors unveiled by electron crystallography

S Inoue, K Nikaido, T Higashino, S Arai… - Chemistry of …, 2021 - ACS Publications
The control of two-dimensional layered crystalline and/or liquid crystalline phases for π-
extended organic molecules is crucial for expanding the potential of organic electronic …

Atomic structure of the predominant GII. 4 human norovirus capsid reveals novel stability and plasticity

L Hu, W Salmen, R Chen, Y Zhou, F Neill… - Nature …, 2022 - nature.com
Human noroviruses (HuNoVs) cause sporadic and epidemic viral gastroenteritis worldwide.
The GII. 4 variants are responsible for most HuNoV infections, and GII. 4 virus-like particles …

Structure-based design of stabilized recombinant influenza neuraminidase tetramers

D Ellis, J Lederhofer, OJ Acton, Y Tsybovsky… - Nature …, 2022 - nature.com
Influenza virus neuraminidase (NA) is a major antiviral drug target and has recently
reemerged as a key target of antibody-mediated protective immunity. Here we show that …

[HTML][HTML] Cryo-EM structure of the human TACAN in a closed state

X Chen, Y Wang, Y Li, X Lu, J Chen, M Li, T Wen, N Liu… - Cell Reports, 2022 - cell.com
TACAN is an ion channel-like protein that may be involved in sensing mechanical pain.
Here, we present the cryo-electron microscopic structure of human TACAN (hTACAN) …

Machine learning-based real-time object locator/evaluator for cryo-EM data collection

K Yonekura, S Maki-Yonekura, H Naitow… - Communications …, 2021 - nature.com
In cryo-electron microscopy (cryo-EM) data collection, locating a target object is error-prone.
Here, we present a machine learning-based approach with a real-time object locator named …