Protein–protein interactions (PPIs) are involved at all levels of cellular organization, thus
making the development of PPI inhibitors extremely valuable. The identification of selective …

The demand for modified peptides with improved stability profiles and pharmacokinetic
properties is driving extensive research effort in this field. Many structural modifications of …

Deuterated organic compounds have widespread applications in many fields such as
medicinal chemistry, mechanistic studies, and quantitative analyses. Traditionally, the …

A new zwitterionic organotrifluoroborate is appended to three radiosynthons that afford
undergo facile bioconjugation to several clinically relevant peptides and one enzyme …

The advent of cycloaddition reactions in the synthesis of heterocycles and their ever
burgeoning applications in the fields of material chemistry, catalysis and drugs have been a …

A mild, versatile organophotoredox protocol has been developed for the preparation of
diverse, enantioenriched α-deuterated α-amino acids. Distinct from the well-established two …

Ralph F. Hirschmann has been a leader in efforts to harness the therapeutic potential of
peptides for 40 years. He recognized the importance of synthetic organic chemistry and …

Abstract Protein‐Protein‐Interaktionen (PPIs) spielen auf allen Ebenen der Zellorganisation
eine wichtige Rolle, was die Entwicklung von PPI‐Inhibitoren äußerst interessant macht. Die …

A photoredox catalytic asymmetric method has been established for the installation of both
aliphatic and aromatic side chains and the introduction of deuterium into the chiral …

A systematic study was performed to establish general synthesis protocols for forming
enantiomerically pure macrocyclic dipeptide lactams. Focusing on macrocycles of 8-, 9-, and …