As we age, we experience changes in our nighttime sleep and daytime wakefulness.
Individuals afflicted with Alzheimer's disease (AD) can develop sleep problems even before …

Nearly half of all adults older than 60 years of age report sleep disturbance, as characterised
either by reports of insomnia complaints with daytime consequences, dissatisfaction with …

Polysomnography (PSG) studies of sleep changes in Alzheimer's disease (AD) have
reported but not fully established the relationship between sleep disturbances and AD. To …

Background Circadian disturbances are commonly seen in people with Alzheimer's disease
and have been reported in individuals without symptoms of dementia but with Alzheimer's …

Pathological proteins contributing to Alzheimer's disease (AD) are known to disrupt normal
neuronal functions in the brain, leading to unbalanced neuronal excitatory-inhibitory tone …

Emerging evidence suggests that sleep deprivation (SD) and circadian rhythm disruption
(CRD) may interact and increase the risk for the development of Alzheimer's disease (AD) …

The brain lacks a classic lymphatic drainage system. How it is cleansed of damaged
proteins, cellular debris, and molecular by-products has remained a mystery for decades …

Alzheimer's disease (AD) is the most common cause of dementia. The APOE-ε4 allele of the
apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset AD. The …

An association with circadian clock function and pathophysiology of aging, major depressive
disorder (MDD), and Alzheimer's disease (AD) is well established and has been proposed …

Sleep deprivation enhances risk for serious injury and fatality on the roads and in
workplaces. To facilitate future management of these risks through advanced detection, we …