Lipids play a diverse and critical role in cellular processes in all tissues. The unique lipid
composition of nerve membranes is particularly interesting because it contains, among other …

The ability to site-selectively modify equivalent functional groups in a molecule has the
potential to streamline syntheses and increase product yields by lowering step counts …

Insulin binds the insulin receptor (IR) and regulates anabolic processes in target tissues.
Impaired IR signalling is associated with multiple diseases, including diabetes, cancer and …

Coronaviruses have been the causative agent of three epidemics and pandemics in the past
two decades, including the ongoing COVID-19 pandemic. A broadly-neutralizing …

The emergence of new therapeutic modalities requires complementary tools for their
efficient syntheses. Availability of methodologies for site-selective modification of …

Activation of insulin receptor (IR) initiates a cascade of conformational changes and
autophosphorylation events. Herein, we determined three structures of IR trapped by …

The binding of insulin to the insulin receptor (IR) triggers a cascade of receptor
conformational changes and autophosphorylation, leading to the activation of metabolic and …

Nutrient intake is obligatory for animal growth and development, but nutrients alone are not
sufficient. Indeed, insulin and homologous hormones are required for normal growth even in …

The past few years have seen exciting discoveries in the area of tyrosine kinase structural
biology including the first high resolution models of full-length receptor tyrosine kinases and …

Insulin is a peptide hormone essential for maintaining normal blood glucose levels.
Individuals unable to secrete sufficient insulin or not able to respond properly to insulin …