Cortical-subcortical interactions in goal-directed behavior

KG Cruz, YN Leow, NM Le, E Adam… - Physiological …, 2023 - journals.physiology.org
Flexibly selecting appropriate actions in response to complex, ever-changing environments
requires both cortical and subcortical regions, which are typically described as participating …

Optogenetic fMRI for brain-wide circuit analysis of sensory processing

JY Lee, T You, CW Woo, SG Kim - International Journal of Molecular …, 2022 - mdpi.com
Sensory processing is a complex neurological process that receives, integrates, and
responds to information from one's own body and environment, which is closely related to …

Emergence of cortical network motifs for short-term memory during learning

XW Chia, JK Tan, LF Ang, T Kamigaki… - Nature …, 2023 - nature.com
Learning of adaptive behaviors requires the refinement of coordinated activity across
multiple brain regions. However, how neural communications develop during learning …

Optimal anticipatory control as a theory of motor preparation: A thalamo-cortical circuit model

TC Kao, MS Sadabadi, G Hennequin - Neuron, 2021 - cell.com
Across a range of motor and cognitive tasks, cortical activity can be accurately described by
low-dimensional dynamics unfolding from specific initial conditions on every trial. These" …

Parvalbumin interneuron activity drives fast inhibition-induced vasoconstriction followed by slow substance P-mediated vasodilation

TT Vo, GH Im, K Han, M Suh… - Proceedings of the …, 2023 - National Acad Sciences
The role of parvalbumin (PV) interneurons in vascular control is poorly understood. Here, we
investigated the hemodynamic responses elicited by optogenetic stimulation of PV …

Microglia modulate stable wakefulness via the thalamic reticular nucleus in mice

H Liu, X Wang, L Chen, L Chen, SE Tsirka, S Ge… - Nature …, 2021 - nature.com
Microglia are important for brain homeostasis and immunity, but their role in regulating
vigilance remains unclear. We employed genetic, physiological, and metabolomic methods …

Multi-scale light-sheet fluorescence microscopy for fast whole brain imaging

Z Zhang, X Yao, X Yin, Z Ding, T Huang… - Frontiers in …, 2021 - frontiersin.org
Whole-brain imaging has become an increasingly important approach to investigate neural
structures, such as somata distribution, dendritic morphology, and axonal projection …

Dissection of brain-wide resting-state and functional somatosensory circuits by fMRI with optogenetic silencing

WB Jung, H Jiang, S Lee… - Proceedings of the …, 2022 - National Acad Sciences
To further advance functional MRI (fMRI)–based brain science, it is critical to dissect fMRI
activity at the circuit level. To achieve this goal, we combined brain-wide fMRI with neuronal …

A cortico-basal ganglia-thalamo-cortical channel underlying short-term memory

Y Wang, X Yin, Z Zhang, J Li, W Zhao, ZV Guo - Neuron, 2021 - cell.com
Persistent activity underlying short-term memory encodes sensory information or instructs
specific future movement and, consequently, has a crucial role in cognition. Despite …

[HTML][HTML] In vivo labeling and quantitative imaging of neuronal populations using MRI

S Li, X Xu, C Li, Z Xu, K Wu, Q Ye, Y Zhang, X Jiang… - NeuroImage, 2023 - Elsevier
The study of neural circuits, which underlies perception, cognition, emotion, and behavior, is
essential for understanding the mammalian brain, a complex organ consisting of billions of …