The schlafen family of proteins and their regulation by interferons
E Mavrommatis, EN Fish… - Journal of Interferon & …, 2013 - liebertpub.com
The Schlafen (SLFN) family of proteins includes several mouse and human members. There
is emerging evidence that members of this family of proteins are involved in important …
is emerging evidence that members of this family of proteins are involved in important …
The Schlafen family: complex roles in different cell types and virus replication
F Liu, P Zhou, Q Wang, M Zhang… - Cell biology …, 2018 - Wiley Online Library
The Schlafen (slfn) gene family members express broadly, but the research has mainly
focused on human slfn (h‐slfn) and mouse slfn (m‐slfn). The slfn members can be divided …
focused on human slfn (h‐slfn) and mouse slfn (m‐slfn). The slfn members can be divided …
Structure of Schlafen13 reveals a new class of tRNA/rRNA-targeting RNase engaged in translational control
Cleavage of transfer (t) RNA and ribosomal (r) RNA are critical and conserved steps of
translational control for cells to overcome varied environmental stresses. However, enzymes …
translational control for cells to overcome varied environmental stresses. However, enzymes …
Structural and biochemical characterization of human Schlafen 5
FJ Metzner, E Huber, KP Hopfner… - Nucleic Acids …, 2022 - academic.oup.com
The Schlafen family belongs to the interferon-stimulated genes and its members are
involved in cell cycle regulation, T cell quiescence, inhibition of viral replication, DNA-repair …
involved in cell cycle regulation, T cell quiescence, inhibition of viral replication, DNA-repair …
A robust and highly efficient immune cell reprogramming system
LH Bussmann, A Schubert, TPV Manh, L De Andres… - Cell stem cell, 2009 - cell.com
Here we describe a lineage reprogramming system consisting of a B cell line with an
estradiol-inducible form of C/EBPα where cells can be converted into macrophage-like cells …
estradiol-inducible form of C/EBPα where cells can be converted into macrophage-like cells …
SLFN14 mutations underlie thrombocytopenia with excessive bleeding and platelet secretion defects
SJ Fletcher, B Johnson, GC Lowe… - The Journal of …, 2015 - Am Soc Clin Investig
Inherited thrombocytopenias are a group of disorders that are characterized by a low platelet
count and are sometimes associated with excessive bleeding that ranges from mild to …
count and are sometimes associated with excessive bleeding that ranges from mild to …
Evolution of the Schlafen genes, a gene family associated with embryonic lethality, meiotic drive, immune processes and orthopoxvirus virulence
O Bustos, S Naik, G Ayers, C Casola… - Gene, 2009 - Elsevier
Genes of the Schlafen family, first discovered in mouse, are expressed in hematopoietic
cells and are involved in immune processes. Previous results showed that they are …
cells and are involved in immune processes. Previous results showed that they are …
The retroelement Lx9 puts a brake on the immune response to virus infection
The notion that mobile units of nucleic acid known as transposable elements can operate as
genomic controlling elements was put forward over six decades ago,. However, it was not …
genomic controlling elements was put forward over six decades ago,. However, it was not …
Role of interferon α (IFNα)-inducible Schlafen-5 in regulation of anchorage-independent growth and invasion of malignant melanoma cells
E Katsoulidis, E Mavrommatis, J Woodard… - Journal of Biological …, 2010 - ASBMB
IFNα exerts potent inhibitory activities against malignant melanoma cells in vitro and in vivo,
but the mechanisms by which it generates its antitumor effects remain unknown. We …
but the mechanisms by which it generates its antitumor effects remain unknown. We …