STING-associated vasculopathy with onset in infancy (SAVI) is a type I interferonopathy
caused by gain-of-function mutations in STING1 encoding stimulator of interferon genes …

A number of systemic autoinflammatory diseases arise from gain-of-function mutations in
genes encoding IL-1–activating inflammasomes or cytoplasmic nucleic acid sensors …

Stimulator of interferon genes (STING) functions downstream of cyclic GMP-AMP synthase in
DNA sensing or as a direct receptor for bacterial cyclic dinucleotides and small molecules to …

Summary 2′, 3′-cGAMP, produced by the DNA sensor cGAS, activates stimulator of
interferon genes (STING) and triggers immune response during infection. Tremendous effort …

Sensing of human immunodeficiency virus type 1 (HIV-1) DNA is mediated by the cyclic
GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling axis. Signal …

Introduction Autoinflammatory diseases (AID) are rare diseases presenting with episodes of
sterile inflammation. These involve multiple organs and can cause both acute organ …

The cGAS-cGAMP-STING pathway is an important innate immune signaling cascade
responsible for the sensing of abnormal cytosolic double-stranded DNA (dsDNA), which is a …

The stimulator of interferon genes (STING) is a critical protein in the activation of the immune
system in response to DNA. It can participate the inflammatory response process by …

Gain-of-function mutations in STING cause STING-associated vasculopathy with onset in
infancy (SAVI) characterized by early-onset systemic inflammation, skin vasculopathy, and …

Evidence has shown that DNA is a pathogen‐associated molecular pattern, posing a unique
challenge in the discrimination between endogenous and foreign DNA. This challenge is …