Viral replication is a process that involves an extremely high turnover of cellular molecules.
Since viruses depend on the host cell to obtain the macromolecules needed for their proper …

Protein lipid modification involves the attachment of hydrophobic groups to proteins via
ester, thioester, amide, or thioether linkages. In this review, the specific click chemical …

HIV assembly and replication proceed through the formation of morphologically distinct
immature and mature viral capsids that are organized by the Gag polyprotein (immature) …

Protein N-myristoylation is an important fatty acylation catalyzed by N-myristoyltransferases
(NMTs), which are ubiquitous enzymes in eukaryotes. Specifically, attachment of a myristoyl …

Protein N-myristoylation is a cotranslational lipidic modification specific to the alpha-amino
group of an N-terminal glycine residue of many eukaryotic and viral proteins. The ubiquitous …

HIV-1 Gag drives a number of events during the genesis of virions and is the only viral
protein required for the assembly of virus-like particles in vitro and in cells. Although a …

HIV forms spherical, membrane-enveloped, pleomorphic virions, 1,000–1,500 Å in diameter,
which contain two copies of its single-stranded, positive-sense RNA genome. Virus particles …

The role of nucleocapsid protein (NC) in the early steps of retroviral replication appears
largely that of a facilitator for reverse transcription and integration. Using a wide variety of …

Assembly of the Gag polyprotein into new viral particles in infected cells is a crucial step in
the retroviral replication cycle. Currently, little is known about the onset of assembly in the …

The HIV-1 structural protein Gag associates with two types of plasma membrane
microdomains, lipid rafts and tetraspanin-enriched microdomains (TEMs), both of which …