Toll-like receptors (TLRs) have a critical role in the pathogenesis and disease course of viral
infections. The induced pro-inflammatory responses result in the disturbance of the …

Idiopathic pulmonary fibrosis (IPF) is a fatal chronic interstitial lung disease (ILD) that affects
lung mechanical functions and gas exchange. IPF is caused by increased fibroblast activity …

The class IB phosphoinositide 3-kinase (PI3K), PI3Kγ, is a master regulator of immune cell
function and a promising drug target for both cancer and inflammatory diseases. Critical to …

Sickle cell disease (SCD) is an inherited disorder resulting from a β-globin gene mutation,
and SCD patients experience erythrocyte sickling, vaso-occlusive episodes (VOE), and …

Spinal cord injury (SCI) is a profound affliction of the central nervous system that often
remains inadequately addressed. Prior research has indicated that endoplasmic reticulum …

Objective To explore the potential targets, signal pathways and biological functions that
mediate the effect of Lianhua Qingwen capsule in improving clinical cure rate of COVID-19 …

Hepatic cell death occurs in response to diverse stimuli such as chemical and physical
damage. The exposure of intracellular contents such as DNA during necrosis induces a …

Beta glucans are found in many natural sources, however, only Baker's Yeast Beta Glucan
(BYBG) has been well documented to have structure–function effects that are associated …

Toll-like receptor 8 (TLR8) recognizes single-stranded RNA of viral and bacterial origin as
well as mediates the secretion of pro-inflammatory cytokines and type I interferons by human …

Background and Objectives: In sickle cell disease (SCD), hepatopathy is a cumulative
consequence of ischemia/reperfusion (I/R) injury from a vaso-occlusive crisis, tissue …