Beyond RAS and BRAF: HER2, a new actionable oncotarget in advanced colorectal cancer

C Guarini, T Grassi, G Pezzicoli, C Porta - International Journal of …, 2021 - mdpi.com
The human epidermal growth factor receptor 2 (HER2) is a well-established oncogenic
driver and a successful therapeutic target in several malignancies, such as breast and …

Prevalence, prognosis and predictive status of HER2 amplification in anti-EGFR-resistant metastatic colorectal cancer

G Wang, Y He, Y Sun, W Wang, X Qian, X Yu… - Clinical and Translational …, 2020 - Springer
Numerous inherent and acquired genetic alterations have been demonstrated with
resistance to anti-epidermal growth factor receptor (anti-EGFR) therapy in metastatic …

Accuracy evaluation of combining gastroscopy, multi-slice spiral CT, Her-2, and tumor markers in gastric cancer staging diagnosis

S Zhao, Y Bi, Z Wang, F Zhang, Y Zhang… - World Journal of Surgical …, 2022 - Springer
Background To evaluate the diagnostic accuracy of single gastroscopy, multi-slice spiral CT,
HER-2 or tumor markers, and their combination in the diagnosis of gastric cancer. Methods …

A comprehensive review on the role of human epidermal growth factor receptor 2 (HER2) as a biomarker in extra-mammary and extra-gastric cancers

F Amisha, P Malik, P Saluja, N Gautam, TH Patel… - Onco, 2023 - mdpi.com
Simple Summary Human epidermal growth factor receptors (HERs) are present in our body
and are responsible for regulating cell growth. When there is an overexpression of …

Assessment of two different HER2 scoring systems and clinical relevance for colorectal cancer

F Liu, C Ren, Y Jin, S Xi, C He, F Wang, Z Wang, R Xu… - Virchows Archiv, 2020 - Springer
Although the positivity of human epidermal growth factor receptor 2 (HER2) is low in
colorectal cancer (CRC), anti-HER2 is becoming a new target therapy in metastatic …

HER2 overexpression/amplification status in colorectal cancer: A comparison between immunohistochemistry and fluorescence in situ hybridization using five different …

Q Sun, Q Li, F Gao, H Wu, Y Fu, J Yang, X Fan… - Journal of Cancer …, 2023 - Springer
Objective Although HER2 has gradually become an important therapeutic target for
colorectal cancer (CRC), a unified and standard HER2 scoring system was still not …

Somatic mutation profiling, tumor-infiltrating leukocytes, tertiary lymphoid structures and PD-L1 protein expression in HER2-amplified colorectal cancer

XT Liu, ZY Kou, H Zhang, J Dong, JH Zhang, YJ Peng… - PeerJ, 2023 - peerj.com
The status of human epidermal growth factor receptor 2 (HER2) for the prognosis in
colorectal cancer (CRC) is controversial, and the characteristics of the somatic mutation …

[HTML][HTML] The Role of Beclin 1 and HER2 in Colorectal Carcinoma; An Immunohistochemical Study

MS Gadallah, M Dawoud, A Abdou - Asian Pacific Journal of …, 2024 - ncbi.nlm.nih.gov
Objective: This study aimed to evaluate the expression of Beclin 1 and HER2 proteins using
immunohistochemistry in CRC tissues compared to colonic adenoma, and to investigate the …

[HTML][HTML] Effect of human epidermal growth factor receptor 2 overexpression in metastatic colorectal cancer on standard chemotherapy outcomes

JY Jang, YK Jeon, SY Jeong, SH Lim… - Journal of …, 2023 - ncbi.nlm.nih.gov
Background In metastatic colorectal cancer (mCRC), the prognostic relevance of the human
epidermal growth factor receptor-2 (HER2) remains controversial. We evaluated the impact …

[HTML][HTML] HER2-neu Expression and Survival in Colorectal Cancer in the South of Egypt; Immunohistochemistry and Genetic Study

HEM El-Deek, MMA Hafez… - … Pacific Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Background: Colorectal cancer (CRC) is a major public health problem and one of leading
cancer related death all over the world. One of the prognostic parameters that play a role in …