The role of inflammation in diabetic retinopathy

JV Forrester, L Kuffova, M Delibegovic - Frontiers in immunology, 2020 - frontiersin.org
Inflammation is central to pathogenic processes in diabetes mellitus and the metabolic
syndrome and particularly implicates innate immunity in the development of complications …

Experimental animal models for diabetes and its related complications—a review

CPD Kottaisamy, DS Raj, V Prasanth Kumar… - Laboratory animal …, 2021 - Springer
Diabetes mellitus, a very common and multifaceted metabolic disorder is considered as one
of the fastest growing public health problems in the world. It is characterized by …

Microglia and inflammatory responses in diabetic retinopathy

UM Kinuthia, A Wolf, T Langmann - Frontiers in immunology, 2020 - frontiersin.org
Diabetic retinopathy is a vision-threatening disease affecting neurons and microvasculature
of the retina. The development of this disease is associated with the action of inflammatory …

Dysregulated CD200-CD200R signaling in early diabetes modulates microglia-mediated retinopathy

CW Pfeifer, JT Walsh, A Santeford… - Proceedings of the …, 2023 - National Acad Sciences
Diabetic retinopathy (DR) is a neurovascular complication of diabetes. Recent investigations
have suggested that early degeneration of the neuroretina may occur prior to the …

The innate immune system in diabetic retinopathy

WW Pan, F Lin, PE Fort - Progress in retinal and eye research, 2021 - Elsevier
The prevalence of diabetes has been rising steadily in the past half-century, along with the
burden of its associated complications, including diabetic retinopathy (DR). DR is currently …

[WITHDRAWN] retinal vasculature in development and diseases

Y Sun, LEH Smith - Annual review of vision science, 2018 - annualreviews.org
This article was withdrawn on October 15, 2020, at the request of the journal editors, with
agreement from the authors, owing to a substantial amount of unattributed or improperly …

Mitochondrial defects drive degenerative retinal diseases

DA Ferrington, CR Fisher, RA Kowluru - Trends in molecular medicine, 2020 - cell.com
Mitochondrial dysfunction is involved in the pathology of two major blinding retinal diseases,
diabetic retinopathy (DR) and age-related macular degeneration (AMD). These diseases …

Human vitreous in proliferative diabetic retinopathy: characterization and translational implications

IM Nawaz, S Rezzola, A Cancarini, A Russo… - Progress in retinal and …, 2019 - Elsevier
Diabetic retinopathy (DR) is one of the leading causes of visual impairment in the working-
age population. DR is a progressive eye disease caused by long-term accumulation of …

[HTML][HTML] Overexpression of METTL3 attenuates high-glucose induced RPE cell pyroptosis by regulating miR-25-3p/PTEN/Akt signaling cascade through DGCR8

X Zha, X Xi, X Fan, M Ma, Y Zhang, Y Yang - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
Abstract Methyltransferase-like protein 3 (METTL3) regulates multiple cell functions and
diseases by modulating N 6-methyladenosine (m 6 A) modifications. However, it is still …

Mechanistic insights into the alterations and regulation of the AKT signaling pathway in diabetic retinopathy

J Li, K Chen, X Li, X Zhang, L Zhang, Q Yang… - Cell Death …, 2023 - nature.com
In the early stages of diabetic retinopathy (DR), diabetes-related hyperglycemia directly
inhibits the AKT signaling pathway by increasing oxidative stress or inhibiting growth factor …