Plant metabolic gene clusters in the multi-omics era

C Zhan, S Shen, C Yang, Z Liu, AR Fernie… - Trends in Plant …, 2022 - cell.com
Secondary metabolism in plants gives rise to a vast array of small-molecule natural
products. The discovery of operon-like gene clusters in plants has provided a new …

Synthetic biology of plant natural products: From pathway elucidation to engineered biosynthesis in plant cells

X Zhu, X Liu, T Liu, Y Wang, N Ahmed, Z Li… - Plant Communications, 2021 - cell.com
Plant natural products (PNPs) are the main sources of drugs, food additives, and new
biofuels and have become a hotspot in synthetic biology. In the past two decades, the …

Progress and prospect: Biosynthesis of plant natural products based on plant chassis

J Lin, X Yin, Y Zeng, X Hong, S Zhang, B Cui… - Biotechnology …, 2023 - Elsevier
Plant-derived natural products are a specific class of active substances with numerous
applications in the medical, energy, and industrial fields. Many of these substances are in …

Making small molecules in plants: a chassis for synthetic biology‐based production of plant natural products

X Liu, P Zhang, Q Zhao… - Journal of Integrative Plant …, 2023 - Wiley Online Library
Plant natural products have been extensively exploited in food, medicine, flavor, cosmetic,
renewable fuel, and other industrial sectors. Synthetic biology has recently emerged as a …

Engineering the Biosynthesis of Late-Stage Vinblastine Precursors Precondylocarpine Acetate, Catharanthine, Tabersonine in Nicotiana benthamiana

D Grzech, B Hong, L Caputi, PD Sonawane… - ACS Synthetic …, 2022 - ACS Publications
Vinblastine is a chemotherapy agent produced by the plant Catharanthus roseus in small
quantities. Currently, vinblastine is sourced by isolation or semisynthesis. Nicotiana …

[HTML][HTML] Engineering Nicotiana benthamiana as a platform for natural product biosynthesis

D Golubova, C Tansley, H Su, NJ Patron - Current Opinion in Plant Biology, 2024 - Elsevier
Nicotiana benthamiana is a model plant, widely used for research. The susceptibility of
young plants to Agrobacterium tumefaciens has been utilised for transient gene expression …

[HTML][HTML] CsAlaDC and CsTSI work coordinately to determine theanine biosynthesis in tea plants (Camellia sinensis L.) and confer high levels of theanine …

B Zhu, J Guo, C Dong, F Li, S Qiao, S Lin… - Plant Biotechnology …, 2021 - ncbi.nlm.nih.gov
Tea, the second most popular nonalcoholic beverage consumed worldwide, is favoured by
billions of consumers due to its special flavour and numerous health benefits (Higdon and …

Plant synthetic biology: from inspiration to augmentation

P Rizzo, BG Chavez, SL Dias, JC D'Auria - Current Opinion in …, 2023 - Elsevier
Highlights•New toolkits allow increased precision and control over gene expression in
planta.•The workflow of synthetic biology includes the phases of design, build, and …

Plant-based expression platforms to produce high-value metabolites and proteins

A Kulshreshtha, S Sharma, CS Padilla… - Frontiers in plant …, 2022 - frontiersin.org
Plant-based heterologous expression systems can be leveraged to produce high-value
therapeutics, industrially important proteins, metabolites, and bioproducts. The production …

Engineering of triterpene metabolism and overexpression of the lignin biosynthesis gene PAL promotes ginsenoside Rg3 accumulation in ginseng plant chassis

L Yao, H Zhang, Y Liu, Q Ji, J Xie… - Journal of Integrative …, 2022 - Wiley Online Library
The ginsenoside Rg3 found in Panax species has extensive pharmacological properties, in
particular anti‐cancer effects. However, its natural yield in Panax plants is limited. Here, we …