Nucleic acid vaccines for hepatitis B and C virus
S Karimkhanilouyi, S Ghorbian - Infection, Genetics and Evolution, 2019 - Elsevier
Hepatitis B virus (HBV) and Hepatitis C virus (HCV) infections accounts for an important
global health problem affecting over 250 million people all around the world. They can …
global health problem affecting over 250 million people all around the world. They can …
Immunogenicity of CIGB‐230, a therapeutic DNA vaccine preparation, in HCV‐chronically infected individuals in a Phase I clinical trial
L Alvarez‐Lajonchere, NH Shoukry, B Gra… - Journal of viral …, 2009 - Wiley Online Library
Hepatitis C virus (HCV) is a worldwide health problem. No vaccine is available against this
pathogen and therapeutic treatments currently in use are of limited efficacy. In the present …
pathogen and therapeutic treatments currently in use are of limited efficacy. In the present …
Intrinsic disorder in the core proteins of flaviviruses
R Ivanyi-Nagy, JL Darlix - Protein and Peptide Letters, 2010 - ingentaconnect.com
Hepatitis C virus and related viruses in the Flaviviridae family (such as dengue virus, yellow
fever virus or West Nile virus) are amongst the most important human pathogens, causing …
fever virus or West Nile virus) are amongst the most important human pathogens, causing …
Protective T cell and antibody immune responses against hepatitis C virus achieved using a biopolyester-bead-based vaccine delivery system
G Martínez-Donato, B Piniella, D Aguilar… - Clinical and Vaccine …, 2016 - Am Soc Microbiol
Hepatitis C virus (HCV) infection is a major worldwide problem. Chronic hepatitis C is
recognized as one of the major causes of cirrhosis, hepatocellular carcinoma, and liver …
recognized as one of the major causes of cirrhosis, hepatocellular carcinoma, and liver …
HCV core protein immunization with Montanide/CpG elicits strong Th1/Th2 and long-lived CTL responses
An efficient vaccine against Hepatitis C virus (HCV) infection requires induction of strong
humoral and cellular responses against viral proteins. We evaluated the immunogenicity of …
humoral and cellular responses against viral proteins. We evaluated the immunogenicity of …
[HTML][HTML] Virus-Like Particles as vaccine antigens and adjuvants: application to chronic disease, cancer immunotherapy and infectious disease preventive strategies
G Guillén, JC Aguilar, S Dueñas, L Hermida… - Procedia in …, 2010 - Elsevier
Existing vaccines are mainly limited to the microorganisms we are able to culture and
produce and/or to those whose killing is mediated by humoral responses. It has been more …
produce and/or to those whose killing is mediated by humoral responses. It has been more …
The interaction of dengue virus capsid protein with negatively charged interfaces drives the in vitro assembly of nucleocapsid-like particles
NC Mebus-Antunes, WS Ferreira, GM Barbosa… - PLoS …, 2022 - journals.plos.org
Dengue virus (DENV) causes a major arthropod-borne viral disease, with 2.5 billion people
living in risk areas. DENV consists in a 50 nm-diameter enveloped particle in which the …
living in risk areas. DENV consists in a 50 nm-diameter enveloped particle in which the …
Immunization with a DNA vaccine candidate in chronic hepatitis C patients is safe, well tolerated and does not impair immune response induction after anti‐hepatitis B …
M Castellanos, Z Cinza, Z Dorta, G Veliz… - The journal of gene …, 2010 - Wiley Online Library
Background In the present study, we evaluated the safety of CIGB‐230, a novel vaccine
candidate based on the mixture of a plasmid for DNA immunization, expressing hepatitis C …
candidate based on the mixture of a plasmid for DNA immunization, expressing hepatitis C …
[HTML][HTML] HCV-specific immune responses induced by CIGB-230 in combination with IFN-α plus ribavirin
Y Amador-Cañizares, G Martínez-Donato… - World Journal of …, 2014 - ncbi.nlm.nih.gov
AIM: To analyze hepatitis C virus (HCV)-specific immune responses in chronically infected
patients under triple therapy with interferon-α (IFN-α) plus ribavirin and CIGB-230 …
patients under triple therapy with interferon-α (IFN-α) plus ribavirin and CIGB-230 …
Hepatitis C virus (HCV) core protein enhances the immunogenicity of a co‐delivered DNA vaccine encoding HCV structural antigens in mice
L Alvarez‐Lajonchere, M González… - Biotechnology and …, 2006 - Wiley Online Library
In the present study, recombinant HCV (hepatitis C virus) core proteins enhanced the
immune response elicited by a co‐delivered DNA vaccine encoding HCV core and …
immune response elicited by a co‐delivered DNA vaccine encoding HCV core and …