Mitochondrial dysfunction: roles in skeletal muscle atrophy
X Chen, Y Ji, R Liu, X Zhu, K Wang, X Yang… - Journal of Translational …, 2023 - Springer
Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle
health, and damage to mitochondria can lead to a series of pathophysiological changes …
health, and damage to mitochondria can lead to a series of pathophysiological changes …
Cannabidiol and neurodegeneration: From molecular mechanisms to clinical benefits
Neurodegenerative disorders (NDs) such as Alzheimer's disease, Parkinson's disease,
Huntington's disease, multiple sclerosis, and amyotrophic lateral sclerosis are severe and …
Huntington's disease, multiple sclerosis, and amyotrophic lateral sclerosis are severe and …
LSD1/PRMT6-targeting gene therapy to attenuate androgen receptor toxic gain-of-function ameliorates spinobulbar muscular atrophy phenotypes in flies and mice
R Prakasam, A Bonadiman, R Andreotti… - Nature …, 2023 - nature.com
Spinobulbar muscular atrophy (SBMA) is caused by CAG expansions in the androgen
receptor gene. Androgen binding to polyQ-expanded androgen receptor triggers SBMA …
receptor gene. Androgen binding to polyQ-expanded androgen receptor triggers SBMA …
Androgen receptor coordinates muscle metabolic and contractile functions
K Ghaibour, M Schuh, S Souali‐Crespo… - Journal of Cachexia …, 2023 - Wiley Online Library
Background Androgens are anabolic steroid hormones that exert their function by binding to
the androgen receptor (AR). We have previously established that AR deficiency in limb …
the androgen receptor (AR). We have previously established that AR deficiency in limb …
Therapeutic strategies to target the androgen receptor
The androgen receptor (AR) plays a key role in the maintenance of muscle and bone and
the support of male sexual-related functions, as well as in the progression of prostate …
the support of male sexual-related functions, as well as in the progression of prostate …
A comprehensive review of protein misfolding disorders, underlying mechanism, clinical diagnosis, and therapeutic strategies
Introduction The most prevalent biological macromolecules in living systems are proteins,
the building block of life, extremely dynamic in structure and functions. Due to several …
the building block of life, extremely dynamic in structure and functions. Due to several …
Gene therapy with AR isoform 2 rescues spinal and bulbar muscular atrophy phenotype by modulating AR transcriptional activity
Spinal and bulbar muscular atrophy (SBMA) is an X-linked, adult-onset neuromuscular
condition caused by an abnormal polyglutamine (polyQ) tract expansion in androgen …
condition caused by an abnormal polyglutamine (polyQ) tract expansion in androgen …
Neuromuscular junction pathology is correlated with differential motor unit vulnerability in spinal and bulbar muscular atrophy
E Molotsky, Y Liu, AP Lieberman, DE Merry - Acta Neuropathologica …, 2022 - Springer
Spinal and bulbar muscular atrophy (SBMA) is an X-linked, neuromuscular
neurodegenerative disease for which there is no cure. The disease is characterized by a …
neurodegenerative disease for which there is no cure. The disease is characterized by a …
[HTML][HTML] An overview on androgen-mediated actions in skeletal muscle and adipose tissue
J Rizk, R Sahu, D Duteil - Steroids, 2023 - Elsevier
Androgens are a class of steroid hormones primarily associated with male sexual
development and physiology, but exert pleiotropic effects in either sex. They have a crucial …
development and physiology, but exert pleiotropic effects in either sex. They have a crucial …
Defective excitation-contraction coupling and mitochondrial respiration precede mitochondrial Ca2+ accumulation in spinobulbar muscular atrophy skeletal muscle
Polyglutamine expansion in the androgen receptor (AR) causes spinobulbar muscular
atrophy (SBMA). Skeletal muscle is a primary site of toxicity; however, the current …
atrophy (SBMA). Skeletal muscle is a primary site of toxicity; however, the current …