Kinetic mechanism of DNA polymerases: contributions of conformational dynamics and a third divalent metal ion
Faithful transmission and maintenance of genetic material is primarily fulfilled by DNA
polymerases. During DNA replication, these enzymes catalyze incorporation of …
polymerases. During DNA replication, these enzymes catalyze incorporation of …
Physics of biomolecular recognition and conformational dynamics
Biomolecular recognition usually leads to the formation of binding complexes, often
accompanied by large-scale conformational changes. This process is fundamental to …
accompanied by large-scale conformational changes. This process is fundamental to …
Investigating the conformational dynamics of a Y-family DNA polymerase during its folding and binding to DNA and a nucleotide
During DNA polymerization, the Y-family DNA polymerases are capable of bypassing
various DNA damage, which can stall the replication fork progression. It has been well …
various DNA damage, which can stall the replication fork progression. It has been well …
Investigating the trade-off between folding and function in a multidomain Y-family DNA polymerase
The way in which multidomain proteins fold has been a puzzling question for decades. Until
now, the mechanisms and functions of domain interactions involved in multidomain protein …
now, the mechanisms and functions of domain interactions involved in multidomain protein …
[图书][B] Structure and Dynamic Studies of Dpo4
E Lee - 2020 - search.proquest.com
Cellular DNA is constantly challenged by endogenous and environmental stress such as UV
radiation and oxidative species, resulting a variety of lesions that can be bypassed by the Y …
radiation and oxidative species, resulting a variety of lesions that can be bypassed by the Y …
Mechanistic Studies of DNA Replication, Lesion Bypass, and Editing
AT Raper - 2018 - rave.ohiolink.edu
DNA acts as a molecular blueprint for life. Adenosine, cytidine, guanosine, and thymidine
nucleotides serve as the building blocks of DNA and can be arranged in near-endless …
nucleotides serve as the building blocks of DNA and can be arranged in near-endless …
A Structural and Biochemical Investigation of Human DNA Polymerase Beta
AJ Reed - 2018 - rave.ohiolink.edu
Adenosine, guanosine, cytidine, and thymidine nucleotides are the building blocks of life
and are arranged in distinct combinations to give unique genomic DNA sequences. These …
and are arranged in distinct combinations to give unique genomic DNA sequences. These …