The eukaryotic 26S proteasome is a large multisubunit complex that degrades the majority
of proteins in the cell under normal conditions. The 26S proteasome can be divided into two …

ATPases associated with diverse cellular activities (AAA+ proteins) are macromolecular
machines that convert the chemical energy contained in ATP molecules into powerful …

AAA+ family proteolytic machines (ClpXP, ClpAP, ClpCP, HslUV, Lon, FtsH, PAN/20S, and
the 26S proteasome) perform protein quality control and are used in regulatory circuits in all …

The proteasome has emerged as an intricate machine that has dynamic mechanisms to
regulate the timing of its activity, its selection of substrates, and its processivity. The 19 …

The 26S proteasome is at the executive end of the ubiquitin-proteasome pathway for the
controlled degradation of intracellular proteins. While the structure of its 20S core particle …

The eukaryotic ubiquitin-proteasome system is responsible for most aspects of regulatory
and quality-control protein degradation in cells. Its substrates, which are usually modified by …

The ubiquitin proteasome system (UPS) is the main ATP-dependent protein degradation
pathway in the cytosol and nucleus of eukaryotic cells. At its centre is the 26S proteasome …

Proteasomes degrade a multitude of protein substrates in the cytosol and nucleus, and
thereby are essential for many aspects of cellular function. Because the proteolytic sites are …

The 26S proteasome operates at the executive end of the ubiquitin-proteasome pathway.
Here, we present a cryo-EM structure of the Saccharomyces cerevisiae 26S proteasome at a …

The proteasome refers to a collection of complexes centered on the 20S proteasome core
particle (20S CP), a complex of 28 subunits that houses proteolytic sites in its hollow interior …