Neglected tropical diseases (NTDs) are prevalent in tropical and subtropical countries, and
schistosomiasis is among the most relevant diseases worldwide. In addition, one of the two …

Atorvastatin (AVA) is a third-generation statin with several pleiotropic effects, considered the
last synthetic pharmaceutical blockbuster. Recently, our group described the effects of AVA …

N-myristoyltransferase (NMT) is a promising antimalarial drug target. Despite biochemical
similarities between Plasmodium vivax and human NMTs, our recent research demonstrated …

The emergence of drug resistance against the frontline antimalarials is a major challenge in
the treatment of malaria. In view of emerging reports on drug-resistant strains of Plasmodium …

Malaria is an intracellular protozoan parasitic disease caused by Plasmodium species with
significant morbidity and mortality in endemic regions. The complex lifecycle of the parasite …

Background: Cancer is a multifactorial disease, representing one of the leading causes of
death worldwide. On a global estimate, breast cancer is the most frequently occurring cancer …

ABSTRACT Four novel 4-aminoquinoline-isoindolin-1-one hybrids 5a-d have been
designed as antiplasmodial and antioxidant agents by combining the 4-aminoquinoline unit …