Matrix metalloproteinases (MMPs) are a group of over twenty proteases, operating chiefly
extracellularly to cleave components of the extracellular matrix, cell adhesion molecules as …

Perineuronal nets (PNN) are extracellular matrix (ECM) assemblies that preferentially
ensheath parvalbumin (PV) expressing interneurons. Converging evidence indicates that …

Accumulating data support the importance of interactions between pre-and postsynaptic
neuronal elements with astroglial processes and extracellular matrix (ECM) for formation …

Over a billion people worldwide are affected by vitamin D deficiency. Although vitamin D
deficiency is associated with impaired cognition, the mechanisms mediating this link are …

Perineuronal nets (PNNs) in the brain are condensed glycosaminoglycan-rich extracellular
matrix structures with heterogeneous composition yet specific organization. They typically …

Furin is an important mammalian proprotein convertase that catalyzes the proteolytic
maturation of a variety of prohormones and proproteins in the secretory pathway. In the …

Fragile X syndrome (FXS), a heritable intellectual and autism spectrum disorder (ASD),
results from the loss of Fragile X mental retardation protein (FMRP). This …

Major depressive disorder is a complex disease resulting from aberrant synaptic plasticity
that may be caused by abnormal serotonergic signaling. Using a combination of behavioral …

The development of molecular biology methods in the early 1980s led to a better
understanding of the role of transcription factors in mammalian cells. The discovery that …

Numerous brain diseases are associated with abnormalities in morphology and density of
dendritic spines, small membranous protrusions whose structural geometry correlates with …