The interaction between the T‐cell receptor (TCR) and its peptide–major histocompatibility
complex (pepMHC) ligand plays a critical role in determining the activity and specificity of …

In 2007, 1179 papers were published that involved the application of optical biosensors.
Reported developments in instrument hardware, assay design, and immobilization …

The molecular rules that govern MHC restriction, and allow T‐cells to differentiate between
peptides derived from healthy cells and those from diseased cells, remain poorly …

A necessary feature of the immune system, TCR (T-cell receptor) cross-reactivity has been
implicated in numerous autoimmune pathologies and is an underlying cause of transplant …

Protective T cell responses elicited along chronic human CMV (HCMV) infections are
sometimes dominated by CD8 T cell clones bearing highly related or identical public TCR in …

Over the past two decades, structural biology has shown how T‐cell receptors engage
peptide/major histocompatibility complex (MHC) complexes and provided insight into the …

αβ T-cell receptors (TCRs) recognize multiple antigenic peptides bound and presented by
major histocompatibility complex molecules. TCR cross-reactivity has been attributed in part …

Our goal is to provide a perspective on current understanding of the origins of specificity in
immune reactions, a topic that has intrigued scientists for over a century. A fundamental …

Experimental work has shown that T cells of the immune system rapidly and specifically
respond to antigenic molecules presented on the surface of antigen-presenting-cells and …

Structural biology of peptides presented by class I and class II MHC proteins has
transformed immunology, impacting our understanding of fundamental immune mechanisms …