Mechanical properties of extracellular matrices (ECMs) regulate essential cell behaviours,
including differentiation, migration and proliferation, through mechanotransduction. Studies …

Metastatic cancer is almost always terminal, and more than 90% of cancer deaths result from
metastatic disease. Combating cancer metastasis and post-therapeutic recurrence …

CD44, a non-kinase cell surface transmembrane glycoprotein, has been widely implicated
as a cancer stem cell (CSC) marker in several cancers. Cells overexpressing CD44 possess …

Tissue engineering has produced innovative tools for cancer research. 3D cancer models
based on molecularly designed biomaterials aim to harness the dimensionality and …

Extracellular matrix is a complex network of macromolecules that constitute a
microenvironment of normal tissues and malignancies such as the primary brain tumor …

Gliomas are a diverse group of primary central nervous system tumors that affect both
children and adults. Recent studies have revealed a dynamic cross talk that occurs between …

Plasma membrane curvature is an important factor in the regulation of cellular phenotype
and is critical for various cellular activities including the shedding of extracellular vesicles …

In solid tumours, cancer cells that undergo epithelial mesenchymal transition (EMT) express
characteristic gene expression signatures that promote invasive migration as well as the …

The cytoskeleton is a complex network of interconnected biopolymers consisting of actin
filaments, microtubules, and intermediate filaments. These biopolymers work in concert to …

The scaffold protein IQGAP1 assembles multiprotein signaling complexes to influence
biological functions. Cell surface receptors, particularly receptor tyrosine kinases and G …