For many years, the dogma has been that insulin resistance precedes the development of
hyperinsulinemia. However, recent data suggest a reverse order and place …

Hyperinsulinemia is strongly associated with type 2 diabetes. Racial and ethnic minority
populations are disproportionately affected by diabetes and obesity-related complications …

Upon its secretion from pancreatic β-cells, insulin reaches the liver through the portal
circulation to exert its action and eventually undergo clearance in the hepatocytes. In …

Insulin action is impaired in type 2 diabetes. The functions of the hormone are an integrated
product of insulin secretion from pancreatic β-cells and insulin clearance by receptor …

Background It is unclear how excess adiposity and insulin resistance affect β cell function,
insulin secretion, and insulin clearance in people with obesity. Methods We used a …

Insulin receptor (INSR) has been extensively studied in the area of cell proliferation and
energy metabolism. Impaired INSR activities lead to insulin resistance, the key factor in the …

Plasma insulin clearance is an important determinant of plasma insulin concentration. In this
review, we provide an overview of the factors that regulate insulin removal from plasma and …

It has long been hoped that our understanding of the pathogenesis of diabetes would be
helped by the use of mathematical modeling. In 1979 Richard Bergman and Claudio Cobelli …

There is wide variance among individuals in the fraction of insulin cleared by the liver (20%
to 80%). Hepatic insulin clearance is 67% lower in African Americans than European …

BACKGROUND Insulin is a key regulator of metabolic function. The effects of excess
adiposity, insulin resistance, and hepatic steatosis on the complex integration of insulin …